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Macrophage Map
Molecular Interaction Map of Macrophage

A team of researchers at the Systems Biology Institute (SBI), Tokyo Medical and Dental University (TMDU), and Keio University jointly created a large scale molecular interaction map of macrophage. The map is intended to serve analysis framework for the Alliance for Cellular Signaling (AfCS), a large scale NIH-funded project lead by Professor Alfred Gilman (Univ. Texas Southwestern Medical Center).
The map and description of the map is available from

Nature Signaling Gateway
.





REPORT:

Molecular Interaction Map of a Macrophage
Oda K, Kimura T, Matsuoka Y, Funahashi A, Muramatsu M, Kitano H
August 25, 2004

Research Report

  • [Full text]
  • [PDF]

  • new Release Name: Molecular
    Interaction Map of Macrophage Ver.2.0
    (released Dec 2004)

    Features:
    Toll-like receptors (TLRs) signalings via myeloid differentiation primary
    response gene 88 (MyD88) -dependent and MyD88-independent pathways are
    added. As input signals, we selected triacyl lipopeptide for TLR1/TLR2
    complex, double-stranded RNA (ddRNA) for TLR3, flagellin for TLR5,
    lipoprotein for TLR2/TLR6 complex, single-stranded RNA (ssRNA) for TLR7,
    nonmethylated CpG DNA for TLR9. (Reference: Tsan MF, Gao B. Endogenous
    ligands of Toll-like receptors. J Leukoc Biol. 2004 Sep;76(3):514-9.)

    Operating Environment:
    CellDesigner version 2.0

  • MAP in PDF format>>
  • MAP in XML format>>



  • Release Name: Molecular Interaction Map of Macrophage Ver.1.0
    (released: Jun 2004)

    Features:
    This map was created with CellDesigner version 2.0.
    A total number of 506 reactions and 678 species were included.

    ** MAP in PDF format available as part of AfCS Report

    Operating Environment:
    CellDesigner version 2.0

  • MAP in PDF format>>
  • MAP in XML format>>
  •   Copyright © 2003-2007 The Systems Biology Institute, All Rights Reserved.