2.3 SQUARE SQUARE SQUARE SQUARE SQUARE SQUARE inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive inactive inactive active inactive active inactive active inactive active inactive active active active inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive active inactive active inactive inactive inactive active inactive active active inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive active S112 PMID: S136: PMID: 8929531 autophosphorylation: PMID: 1706616 PMID: 1982072 PMID: 11252954 PMID: 10880430 early_br_endsome recycling_br_endsome late_br_endsome lysosome ER inside PROTEIN p1 inside PROTEIN p2 inside PROTEIN p2 PROTEIN p1 inside PROTEIN p2 2 PROTEIN p3 2 PMID: 9667855 PMID: 9779993 inside PROTEIN p2 2 PROTEIN p3 2 inside SIMPLE_MOLECULE ATP inside SIMPLE_MOLECULE ADP inside PROTEIN p4 inside PROTEIN p5 inside SIMPLE_MOLECULE KDI1 inside PROTEIN p6 inside PROTEIN p7 inside PROTEIN p8 inside PROTEIN p6 PROTEIN p8 inside PROTEIN p7 PROTEIN p9 inside PROTEIN p10 inside PROTEIN p12 inside PROTEIN p13 inside PROTEIN p14 inside PROTEIN p15 inside PROTEIN p11 inside PROTEIN p10 PROTEIN p11 PROTEIN p9 inside PROTEIN p16 inside PROTEIN p19 inside PROTEIN p21 inside PROTEIN p7 PROTEIN p21 inside PROTEIN p23 inside PROTEIN p24 inside PROTEIN p24 PROTEIN p23 inside PROTEIN p25 PROTEIN p26 inside PROTEIN p5 PROTEIN p6 PROTEIN p9 inside PROTEIN p27 inside PROTEIN p28 inside PROTEIN p29 inside PROTEIN p7 PROTEIN p30 inside PROTEIN p7 PROTEIN p29 inside PROTEIN p30 inside PROTEIN p32 inside PROTEIN p33 inside PROTEIN p2 2 PROTEIN p3 2 inside PROTEIN p38 inside PROTEIN p7 PROTEIN p38 inside SIMPLE_MOLECULE GDP inside SIMPLE_MOLECULE GTP PROTEIN p39 inside SIMPLE_MOLECULE GTP inside SIMPLE_MOLECULE GDP PROTEIN p39 inside ION Pi inside SIMPLE_MOLECULE GTP PROTEIN p40 inside SIMPLE_MOLECULE GDP PROTEIN p40 inside PROTEIN p41 inside PROTEIN p42 inside PROTEIN p43 inside PROTEIN p16 PROTEIN p44 inside PROTEIN p46 PROTEIN p45 SIMPLE_MOLECULE GTP inside SIMPLE_MOLECULE GDP PROTEIN p45 PROTEIN p46 inside PROTEIN p2 2 inside DEGRADED a152_degraded inside PROTEIN p48 transmembrane PROTEIN p2 2 PROTEIN p47 2 inside PROTEIN p47 2 transmembrane PROTEIN p47 2 inside PROTEIN p49 transmembrane PROTEIN p50 PROTEIN p9 transmembrane PROTEIN p50 transmembrane PROTEIN p50 PROTEIN p52 inside PROTEIN p51 transmembrane PROTEIN p50 PROTEIN p52 inside PROTEIN p53 inside DEGRADED a178_degraded inside PROTEIN p54 inside PROTEIN p55 inside PROTEIN p56 inside DEGRADED a184_degraded inside PROTEIN p57 inside PROTEIN p58 inside PROTEIN p51 PROTEIN p58 inside PROTEIN p7 PROTEIN p59 inside PROTEIN p7 PROTEIN p59 inside PHENOTYPE actin_br_reorganization inside PROTEIN p62 inside PROTEIN p62 inside PHENOTYPE apoptosis inside PROTEIN p63 inside PROTEIN p65 inside PROTEIN p64 inside PROTEIN p66 inside PROTEIN p66 inside DEGRADED a215_degraded inside PROTEIN p67 inside PROTEIN p68 inside PROTEIN p69 inside PROTEIN p70 inside PROTEIN p71 inside PROTEIN p72 inside PROTEIN p73 inside PROTEIN p74 inside PROTEIN p75 inside PROTEIN p76 inside PROTEIN p77 inside PROTEIN p78 inside PROTEIN p79 inside PROTEIN p79 inside PROTEIN p80 inside PROTEIN p85 inside PROTEIN p84 inside PROTEIN p86 inside PROTEIN p50 PROTEIN p8 inside PROTEIN p7 PROTEIN p8 inside PROTEIN p5 PROTEIN p6 PROTEIN p8 inside PROTEIN p97 inside PROTEIN p97 inside GENE c-jun inside RNA m.c-jun inside PROTEIN p98 inside PROTEIN p98 inside PROTEIN p99 inside PROTEIN p99 2 inside GENE p53 inside RNA m.p53 inside PROTEIN p100 inside PROTEIN p100 inside PROTEIN p101 inside GENE c-fos inside RNA m.c-fos inside PROTEIN p102 inside DEGRADED a274_degraded inside DEGRADED a285_degraded inside PROTEIN p102 inside PROTEIN p103 inside PROTEIN p104 inside PROTEIN p105 inside PHENOTYPE target genes_br_transcription inside PROTEIN p107 inside PROTEIN p108 inside PROTEIN p108 inside GENE p21 inside GENE p15 inside RNA m.p15 inside RNA m.p21 inside SIMPLE_MOLECULE PI3,4P_sub_2 inside SIMPLE_MOLECULE PI3,4,5-P_sub_3 inside SIMPLE_MOLECULE PI4,5-P_sub_2 inside SIMPLE_MOLECULE PI4-P inside PROTEIN p110 PROTEIN p26 inside PROTEIN p111 inside PROTEIN p114 inside PROTEIN p117 inside SIMPLE_MOLECULE DAG inside SIMPLE_MOLECULE IP3 inside PROTEIN p118 inside PROTEIN p119 transmembrane PROTEIN p120 transmembrane PROTEIN p120 inside PROTEIN p121 inside PROTEIN p122 inside ION cyt._br_Ca_super_2+ inside ION ER._br_Ca_super_2+ transmembrane PROTEIN p124 transmembrane PROTEIN p124 inside SIMPLE_MOLECULE cADPR inside SIMPLE_MOLECULE cADPR PROTEIN p126 inside SIMPLE_MOLECULE ADPR inside SIMPLE_MOLECULE NAD_super_+ inside PROTEIN p127 inside PROTEIN p128 inside PROTEIN p128 ION cyt._br_Ca_super_2+ inside SIMPLE_MOLECULE phosphatidyl_br_choline inside SIMPLE_MOLECULE choline inside PROTEIN p130 inside PROTEIN p131 inside PROTEIN p130 inside SIMPLE_MOLECULE GTP PROTEIN p132 inside SIMPLE_MOLECULE GDP PROTEIN p132 inside PROTEIN p133 inside PROTEIN p134 inside SIMPLE_MOLECULE GTP PROTEIN p132 inside SIMPLE_MOLECULE cAMP inside SIMPLE_MOLECULE cAMP PROTEIN p136 inside PROTEIN p136 PROTEIN p135 inside PROTEIN p137 inside PROTEIN p138 inside PROTEIN p139 inside PROTEIN p140 inside PROTEIN p141 inside PROTEIN p142 inside PROTEIN p143 inside PROTEIN p144 inside UNKNOWN ? inside PROTEIN p145 inside PROTEIN p146 ION cyt._br_Ca_super_2+ inside PROTEIN p141 inside PROTEIN p143 inside SIMPLE_MOLECULE LPA inside PROTEIN p147 inside PROTEIN p148 inside SIMPLE_MOLECULE LPA PROTEIN p149 inside SIMPLE_MOLECULE LPA PROTEIN p150 inside PROTEIN p155 PROTEIN p156 inside SIMPLE_MOLECULE GDP PROTEIN p153 PROTEIN p155 PROTEIN p156 inside SIMPLE_MOLECULE GDP PROTEIN p153 inside SIMPLE_MOLECULE GTP PROTEIN p153 inside SIMPLE_MOLECULE GDP PROTEIN p152 PROTEIN p155 PROTEIN p156 inside SIMPLE_MOLECULE GTP PROTEIN p152 inside SIMPLE_MOLECULE GDP PROTEIN p152 inside SIMPLE_MOLECULE GDP PROTEIN p151 PROTEIN p155 PROTEIN p156 inside SIMPLE_MOLECULE GDP PROTEIN p151 inside SIMPLE_MOLECULE GTP PROTEIN p151 inside SIMPLE_MOLECULE GTP PROTEIN p154 inside SIMPLE_MOLECULE GDP PROTEIN p154 inside SIMPLE_MOLECULE GDP PROTEIN p154 PROTEIN p155 PROTEIN p156 inside PROTEIN p158 inside PROTEIN p157 inside PROTEIN p158 PROTEIN p157 inside PROTEIN p159 inside PROTEIN p128 ION cyt._br_Ca_super_2+ PROTEIN p160 inside PROTEIN p53 inside PROTEIN p163 inside PROTEIN p169 inside PROTEIN p170 inside SIMPLE_MOLECULE PGE_sub_2 inside SIMPLE_MOLECULE PGE_sub_2 PROTEIN p171 inside SIMPLE_MOLECULE PGE_sub_2 PROTEIN p172 inside PROTEIN p174 inside PROTEIN p175 inside SIMPLE_MOLECULE S1P inside SIMPLE_MOLECULE S1P PROTEIN p176 inside SIMPLE_MOLECULE S1P PROTEIN p177 inside PROTEIN p53 PROTEIN p30 inside PROTEIN p178 inside PROTEIN p179 inside PROTEIN p180 inside PROTEIN p181 inside PROTEIN p182 inside PROTEIN p185 inside PROTEIN p186 inside PROTEIN p183 inside PROTEIN p188 inside PROTEIN p189 inside PROTEIN p190 inside PROTEIN p191 inside PROTEIN p193 inside PROTEIN p194 inside PHENOTYPE mitogenesis inside PHENOTYPE tumorigenesis inside PROTEIN p195 inside GENE cyclin D inside GENE cyclin E inside RNA m.cyclin D inside RNA m.cyclin E inside PROTEIN p196 inside PHENOTYPE cell cycle_br_progression inside PROTEIN p201 inside PROTEIN p202 inside DEGRADED a646_degraded inside PROTEIN p6 inside PROTEIN p4 inside PROTEIN p23 inside PROTEIN p103 inside PROTEIN p83 inside PROTEIN p20 inside PROTEIN p18 inside PROTEIN p17 inside PROTEIN p205 inside PROTEIN p106 inside PROTEIN p106 inside PROTEIN p22 inside PROTEIN p184 inside SIMPLE_MOLECULE phosphatidic_br_acid transmembrane PROTEIN p125 transmembrane PROTEIN p125 PROTEIN p126 inside PROTEIN p122 inside PROTEIN p200 inside PROTEIN p200 PROTEIN p202 inside DEGRADED a687_degraded inside PROTEIN p164 inside PROTEIN p198 inside PROTEIN p198 PROTEIN p196 inside PROTEIN p196 PROTEIN p198 inside PROTEIN p164 PROTEIN p196 PROTEIN p198 inside PROTEIN p60 inside PROTEIN p207 inside PROTEIN p197 inside PROTEIN p197 inside PROTEIN p206 inside PROTEIN p206 inside PROTEIN p129 inside PROTEIN p128 ION cyt._br_Ca_super_2+ PROTEIN p129 inside PROTEIN p128 ION cyt._br_Ca_super_2+ PROTEIN p129 inside PROTEIN p61 inside PROTEIN p113 inside PROTEIN p113 inside PROTEIN p115 inside PROTEIN p112 inside PROTEIN p37 inside PROTEIN p35 inside PROTEIN p34 inside PROTEIN p165 2 inside PROTEIN p166 2 inside PROTEIN p167 2 inside PROTEIN p35 inside PROTEIN p34 inside PROTEIN p208 2 inside PROTEIN p167 2 inside PROTEIN p199 inside PROTEIN p197 PROTEIN p199 inside PROTEIN p197 PROTEIN p199 inside PROTEIN p82 inside PROTEIN p81 inside PROTEIN p82 inside PROTEIN p82 inside PROTEIN p82 inside PROTEIN p209 inside PROTEIN p87 inside PROTEIN p88 inside PROTEIN p88 2 inside PROTEIN p91 2 inside PROTEIN p91 2 inside PROTEIN p93 inside PROTEIN p93 inside PROTEIN p93 inside PROTEIN p93 inside PROTEIN p95 inside PROTEIN p116 inside PROTEIN p94 inside PROTEIN p96 inside PROTEIN p210 inside PROTEIN p211 PMID: 10214951 PMID: 11252954 inside PHENOTYPE EGF / TGF_alpha_ / HB-EGF_br_amphiregulin / biregulin_br_betacellulin / epiregulin ligand: PMID: 10880430 PMID: 11252954 PMID: 10214951 inside PROTEIN p203 PROTEIN p187 ligand: PMID: 10214951 PMID: 11252954 PMID: 10880430 sutophosphorylation: PMID: 10880430 inside PROTEIN p192 PROTEIN p204 PMID: 11252954 PMID: 7834741 PMID: 9708728 HETERODIMER_ASSOCIATION s2,s1 s4 0.3333333333333339,0.0 0.6666666666666661,3.552713678800501E-15 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 0.33333333333333215,-4.440892098500626E-16 0.6666666666666679,-8.881784197001252E-16 0.4236044217020849,0.4068155459245917 a2 a1 a6 PMID: 11252954 PMID: 7834741 PMID: 9708728 HETERODIMER_ASSOCIATION s4,s4 s6 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.333333333333357,-1.1368683772161603E-13 0.6666666666666661,-1.7763568394002505E-15 0.3333333333333357,-1.7763568394002505E-15 0.6666666666666714,0.0 -0.0018470037534839001,0.46143307920131527 a7 a6 a9 autophosphorylation: PMID: 10880430 PMID: 11252954 PMID: 7834741 PMID: 9708728 PMID: 6090945 PMID: 2543678 PMID: 1688559 conformational change: PMID: 10069801 KDI1: PMID: 12842895 STATE_TRANSITION s6 s7 0.33333333333333304,0.0 0.6666666666666665,0.0 a9 a14 a13 a15 a9 a18 SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030 STATE_TRANSITION s7 s6 0.30330338068432905,4.8205275094304056E-5 0.666666666666667,1.7763568394002505E-15 a13 a9 a38 a40 active EGFR: PMID: 12006650 PMID: 8034616 PMID: 9544989 PMID: 7518560 PMID: 7527043 KDI1: PMID: 12842895 STATE_TRANSITION s10 s11 0.28161028375869845,2.3726169530036145E-4 0.38506339676032386,0.001291758118837194 a16 a17 a13 a19 active EGFR: PMID: 12006650 PMID: 11084343 PMID: 7518560 PMID: 7527043 TRANSPORT s13 s14 0.3333333333333339,-1.7763568394002505E-15 0.666666666666667,0.0 a20 a21 a13 PMID: 8479541 PMID: 12006650 HETERODIMER_ASSOCIATION s15,s13 s16 0.3333333333333357,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666643,-1.7763568394002505E-15 0.3333333333333339,0.0 0.6666666666666679,3.552713678800501E-15 0.3333333333333339,0.33333333333333304 a22 a20 a25 active EGFR: PMID: 8479540 PMID: 12006650 PMID: 11084343 TRANSPORT s16 s18 0.33333333333333304,0.0 0.6666666666666661,0.0 a25 a29 a13 active PI3K: PMID: 11395417 PMID: 12515821 binding: PMID: 12127568 PMID: 10499589 HETERODIMER_ASSOCIATION s20,s15 s23 0.3333333333333357,-2.220446049250313E-16 0.6666666666666643,-2.220446049250313E-16 0.3333333333333339,0.0 0.6666666666666679,0.0 0.4422953804733072,-1.670361776175966E-4 0.6666666666666652,1.7763568394002505E-15 0.13931695899768037,0.27448083684349167 a34 a22 a33 a36 a315 active EGFR: PMID: 9733788 TRANSPORT s24 s25 0.33333333333333304,3.552713678800501E-15 0.6666666666666652,-3.552713678800501E-15 a37 a38 a13 active EGFR: PMID: 14560030 TRANSPORT s26 s27 0.33333333333333437,-7.105427357601002E-15 0.6666666666666665,0.0 a39 a40 a13 active EGFR: PMID: 12127568 PMID: 7532293 STATE_TRANSITION s20 s28 0.3333333333333339,0.0 0.6666666666666679,0.0 a34 a41 a13 active EGFR: PMID: 12454019 active PI3K: PMID: 12454019 PMID: 11395417 PMID: 8939609 PMID: 9438848 TRANSPORT s29 s30 0.33333333333333126,0.0 0.666666666666667,1.7763568394002505E-15 a42 a43 a13 a315 active EGFR: PMID: 14560030 TRANSPORT s31 s32 0.3333333333333339,0.0 0.666666666666667,-1.7763568394002505E-15 a44 a45 a13 active EGFR: PMID: 10648629 STATE_TRANSITION s33 s34 0.005486150990140715,-0.0026654242466932487 0.46995835726075086,-0.001599254548011686 a46 a47 a13 Grb2@EGFR.Y1068/1086P: PMID: 11943184 PMID: 10648629 PMID: 10913131 HETERODIMER_ASSOCIATION s14,s33 s37 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.4885663280839445,1.3998922082958387E-4 0.7472606968440747,-3.045014022502457E-4 0.33333333333333126,0.0 0.666666666666667,0.0 0.001981097332517834,0.5044214522930929 a21 a46 a54 a13 SHP2@EGFR: PMID: 12024020 PMID: 15550174 STATE_TRANSITION s34 s33 0.1202326648102634,-0.0017325257603744149 0.387996561674953,-0.002265610609704538 a47 a46 a532 SHP2@EGFR: PMID: 12024020 PMID: 15550174 DISSOCIATION s37 s14,s33 0.41590075086684664,3.387516597506135E-4 0.6666666666666647,3.552713678800501E-15 0.3333333333333357,1.1102230246251565E-15 0.6666666666666714,2.220446049250313E-16 0.3333333333333304,0.0 0.6666666666666679,1.7763568394002505E-15 0.49948960455720837,-0.0017030824131687439 a54 a21 a46 a532 HETERODIMER_ASSOCIATION s38,s39 s40 0.33333333333332815,0.0 0.6666666666666674,0.0 0.3333333333333357,0.0 0.6666666666666643,0.0 0.33333333333333215,-7.105427357601002E-15 0.6666666666666679,-7.105427357601002E-15 0.3333333333333286,0.33333333333333215 a55 a56 a59 Gab1: PMID: 11943184 PMID: 10648629 PMID: 15550174 Gab1@EGFR.Y1068/1086P: PMID: 10648629 STATE_TRANSITION s40 s43 0.33333333333333215,-2.6645352591003757E-15 0.6666666666666661,-4.440892098500626E-15 a59 a67 a47 a54 PMID: 12006650 PMID: 9544989 PMID: 7527043 HETERODIMER_ASSOCIATION s16,s11 s46 0.3333333333333339,-4.440892098500626E-16 0.6666666666666696,-4.440892098500626E-16 0.3333333333333339,4.440892098500626E-15 0.6666666666666679,7.105427357601002E-15 0.33333333333333237,-3.552713678800501E-15 0.6666666666666663,-3.552713678800501E-15 0.6111822922191559,0.3894768631214862 a25 a17 a74 active EGFR: PMID: 10473558 PMID: 1537335 PMID: 1689310 PMID: 1700866 STATE_TRANSITION s47 s48 0.33333333333333215,3.552713678800501E-15 0.6666666666666661,0.0 a75 a76 a13 PMID: 8695788 PMID: 10704819 HETERODIMER_ASSOCIATION s14,s49 s52 0.3333333333333339,2.220446049250313E-16 0.6666666666666661,0.0 0.3333333333333304,-1.7763568394002505E-15 0.6666666666666661,0.0 0.1806223557919635,-0.23138410953956345 0.597177960529792,-0.13323392879696838 -0.6972600997528495,1.0425348129068528 a21 a77 a86 autophosphorylation: PMID: 14963038 PMID: 10704819 STATE_TRANSITION s52 s51 0.2526881730594228,-9.05365234515898E-6 0.4811827980366692,-2.0823400394220926E-5 a86 a80 a86 Galpha 13: PMID: 10821841 PMID: 8849729 GPCR: PMID: 10704819 PMID: 11252954 autophosphorylation: PMID: 14963038 PMID: 10704819 cyt.Ca: PMID: 10704819 PMID: 11252954 STATE_TRANSITION s49 s54 0.33333333333333304,0.0 0.666666666666667,1.7763568394002505E-15 a77 a88 a77 a89 active Pyk2: PMID: 8849729 PMID: 10704819 STATE_TRANSITION s56 s57 0.33333333333333215,8.881784197001252E-16 0.6666666666666679,0.0 a90 a91 a88 a80 Shc@EGFR.Y1148/1173P: PMID: 14750954 PMID: 12048194 STATE_TRANSITION s56 s63 0.3333333333333357,0.0 0.41368710105979334,-9.711307700843719E-4 a90 a97 a17 a90 active c-Src@Shc.Y317: PMID: 9990038 PMID: 7797556 KDI1: PMID: 12842895 PMID: 10075741 STATE_TRANSITION s7 s64 0.3333333333333357,3.9968028886505635E-15 0.6666666666666679,7.549516567451064E-15 a13 a101 a97 a18 PMID: 12522133 HETERODIMER_ASSOCIATION s14,s65 s66 0.33333333333333304,0.0 0.6666666666666652,-1.7763568394002505E-15 0.33333333333333215,1.7763568394002505E-15 0.6666666666666679,0.0 0.3333333333333295,0.0 0.6666666666666661,0.0 0.7614941699784517,0.23628749199903343 a21 a102 a105 active SOS: PMID: 12006650 PMID: 8479541 PMID: 10740269 GDP-GTP exchange: PMID: 12006650 PMID: 10740269 STATE_TRANSITION s71 s70 0.3333333333333339,1.7763568394002505E-15 0.6666666666666696,-1.7763568394002505E-15 a113 a110 a112 a111 a74 a29 a160 RasGAP@EGFR.Y992P:PMID: 14663478 PMID: 10740269 hydrolysis: PMID: 14663478 STATE_TRANSITION s70 s71 0.44535452799750397,-0.014926993140748301 0.7703368909451163,0.0037545771880944656 a112 a113 a115 a112 a45 active Rin1@GTP+Ras: PMID: 11703925 GDP-GTP exchange: PMID: 11703925 STATE_TRANSITION s76 s75 0.2643571661433386,0.0 0.5907928827576718,2.220446049250313E-15 a123 a117 a122 a118 a126 active RN-tre: PMID: 11099046 STATE_TRANSITION s75 s76 0.33333333333333215,0.0 0.6666666666666661,0.0 a122 a123 a124 a122 a131 GTP+Ras: PMID: 11703925 PMID: 9144171 PMID: 8987396 STATE_TRANSITION s77 s78 0.3333333333333304,0.0 0.6666666666666661,-1.7763568394002505E-15 a125 a126 a112 PMID: 11099046 HETERODIMER_ASSOCIATION s79,s28 s81 0.33333333333333925,-3.552713678800501E-15 0.6666666666666714,-1.7763568394002505E-15 0.3333333333333339,3.552713678800501E-15 0.6666666666666661,3.552713678800501E-15 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 0.5237861925087977,0.4713389521889164 a127 a41 a131 Vav2@EGFR.Y992/1148P: PMID: 12454019 active SOS: PMID: 12127568 GDP-GTP exchange: PMID: 12454019 PMID: 12127568 STATE_TRANSITION s89 s87 0.3333333333333339,0.0 0.6791613413292661,-3.567184589901018E-4 a146 a133 a144 a134 a43 a36 hydrolysis: PMID: 14663478 beta2-chimaerin (RacGAP): PMID: 1903516 PMID: 8496137 PMID: 11278894 STATE_TRANSITION s87 s89 0.30513113572773887,-0.002321052132918666 0.666666666666667,0.0 a144 a146 a147 a144 a709 GTP+Rab5a: PMID: 11703925 PMID: 11062256 TRANSPORT s7 s93 0.33333333333333326,2.220446049250313E-16 0.7411817567011658,-3.243997091384454E-5 a13 a150 a122 DISSOCIATION s93 s92,s90 0.3333333333333326,0.0 0.666666666666667,1.7763568394002505E-15 0.3333333333333339,0.0 0.6666666666666643,0.0 0.33805262571012706,-0.006195327824913832 0.6666666666666661,8.881784197001252E-16 0.026199476792751142,0.42586018202581055 a150 a152 a153 STATE_TRANSITION s92 s94 0.33333333333333215,-8.881784197001252E-16 0.6666666666666643,-8.881784197001252E-16 a152 a154 active PKC: PMID: 10816576 STATE_TRANSITION s90 s96 0.3333333333333335,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 a153 a155 a156 PMID: 10816576 UNKNOWN_TRANSITION s96 s98 0.3333333333333335,4.440892098500626E-16 0.6666666666666669,0.0 a155 a157 recycling: PMID: 10816576 SHP1@EGFR.Y1173P: PMID: 9733788 SHP2@EGFR: PMID: 14560030 TRANSPORT s98 s1 0.3333333333333335,-1.1102230246251565E-16 0.6666666666666667,-3.3306690738754696E-16 a157 a1 a40 a38 early end. EGFR: PMID: 12006650 TRANSPORT s16 s101 -0.06298863401463262,-0.11324331437794077 0.7144854670645298,-0.036055269592456085 a25 a160 a153 early end.EGFR: PMID: 12006650 PMID: 11084343 TRANSPORT s13 s99 0.9224719306793838,1.2119582300462728E-4 0.9356509604774839,3.6453154467941395E-4 a20 a166 a153 early end.EGFR: PMID: 15210722 c-Cbl: PMID: 10635327 HETERODIMER_ASSOCIATION s99,s103 s105 0.3333333333333357,0.0 0.6666666666666679,0.0 0.22543694226114808,-0.2970599289827325 0.4298671106700481,-0.5584765003753818 0.33333333333333215,0.0 0.6666666666666661,0.0 9.562255614508075E-4,0.7394492481122406 a166 a168 a172 a153 active c-Src: PMID: 12456688 PMID: 15210722 PMID: 11448952 PMID: 11994282 STATE_TRANSITION s105 s106 0.34454565849221774,9.709463238083416E-6 0.6666666666666679,-3.552713678800501E-15 a172 a176 a177 c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 11448952 STATE_TRANSITION s107 s108 0.438173665596588,-4.1465151205921646E-4 0.666666666666667,-1.7763568394002505E-15 a177 a178 a176 PMID: 12456688 PMID: 11448952 STATE_TRANSITION s108 s110 0.3333333333333339,0.0 0.6666666666666679,0.0 a178 a180 c-Cbl@EGFR.Y1045P: PMID: 12456688 PMID: 15210722 PMID: 10531381 PMID: 11448952 PMID: 9851973 Ubc-H7: PMID: 15210722 PMID: 10531381 PMID: 11448952 TRANSPORT s90 s114 0.33333333333333304,0.0 0.6666666666666665,-2.220446049250313E-16 a153 a183 a176 a182 PMID: 11448952 PMID: 15210722 TRANSPORT s114 s115 0.33333333333333326,0.0 0.6666666666666667,0.0 a183 a184 PMID: 11448952 PMID: 15210722 STATE_TRANSITION s115 s116 0.33333333333333304,0.0 0.6666666666666661,0.0 a184 a185 early end. EGFR: PMID: 10887178 TRANSPORT s117 s118 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666679,-8.881784197001252E-16 a186 a187 a153 PMID: 11053437 HETERODIMER_ASSOCIATION s103,s118 s119 0.3333333333333346,0.0 0.6666666666666667,0.0 0.3333333333333357,3.552713678800501E-15 0.6666666666666643,0.0 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,0.0 0.3333333333333357,0.33333333333333215 a168 a187 a190 GTP+Rac+Cdc42: PMID: 11950587 PMID: 10551809 PMID: 10559936 PMID: 12522133 PMID: 8107774 TRANSPORT s66 s124 0.33333333333333304,0.0 0.6666666666666661,-1.7763568394002505E-15 a105 a200 a144 autophosphorylation: PMID: 11950587 PMID: 10551809 STATE_TRANSITION s124 s125 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a200 a204 a200 PAK1@GTP+Rac/Cdc42: PMID: 11950587 PMID: 10559936 STATE_TRANSITION s126 s127 0.33333333333333215,-3.552713678800501E-15 0.6666666666666643,0.0 a205 a206 a204 STATE_TRANSITION s127 s128 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666679,0.0 a206 a207 active PKB/Akt: PMID: 9346240 PMID: 12829245 PMID: 15209377 PAK1@GTP+Rac/Cdc42: PMID: 11950587 PMID: 10611223 STATE_TRANSITION s129 s130 0.6400659021376676,0.0022082270483281263 0.7648210886840552,7.066326554614477E-4 a208 a209 a204 a322 PMID: 15209377 INHIBITION s130 s131 0.3333333333333346,-1.7763568394002505E-15 0.6666666666666667,-1.7763568394002505E-15 a209 a210 GTP+Rac+Cdc42: PMID: 7493928 TRANSPORT s132 s133 0.3333333333333339,-8.881784197001252E-16 0.43410852713178727,0.0 a211 a212 a144 GTP+Ras+Cdc42: PMID: 9305638 TRANSPORT s134 s135 0.33333333333333215,1.7763568394002505E-15 0.6666666666666643,1.7763568394002505E-15 a213 a214 a144 MEKK1@GTR+Rac1/Cdc42: PMID: 12456688 PMID: 12049732 STATE_TRANSITION s135 s136 0.3333333333333339,1.0658141036401503E-14 0.6666666666666679,2.3092638912203256E-14 a214 a215 a214 PMID: 12456688 PMID: 12049732 STATE_TRANSITION s136 s137 0.3333333333333357,0.0 0.6666666666666679,0.0 a215 a216 GTP+Rac+Cdc42: PMID: 9305638 TRANSPORT s138 s139 0.33333333333333215,1.7763568394002505E-15 0.6666666666666643,1.0658141036401503E-14 a217 a218 a144 MKL3@GTP+Rac1/Cdc42: PMID: 9003778 STATE_TRANSITION s140 s141 0.3333333333333357,0.0 0.6666666666666643,1.7763568394002505E-15 a219 a220 a212 MLK3@GTP+Rac/Cdc42: PMID: 9003778 STATE_TRANSITION s142 s143 0.3116666666666674,0.0 0.6961111111111151,-3.552713678800501E-15 a221 a222 a212 active MKK3: PMID: 8622669 active MKK4: PMID: 8622669 PMID: 9582321 active MKK6: PMID: 8622669 STATE_TRANSITION s144 s145 0.3333333333333304,-1.7763568394002505E-15 0.6666666666666625,0.0 a223 a224 a222 a220 a226 MEKK4@GTP+Rac1+Cdc42: PMID: 15731347 MEKK1@GTP+Rac1/Cdc42: PMID: 12456688 PMID: 9582321 MLK3@GTP+Rac1/Cdc42: PMID: 9003778 STATE_TRANSITION s146 s147 0.11111111111111072,-3.552713678800501E-15 0.6190476190476204,-3.552713678800501E-15 a225 a226 a218 a214 a212 MEKK1@GTP+Rac1/Cdc42: PMID: 9305750 PMID: 9312068 STATE_TRANSITION s148 s149 0.33333333333333215,-7.105427357601002E-15 0.6666666666666643,-1.0658141036401503E-14 a227 a228 a214 active MKK4: PMID: 12624093 PMID: 8622669 PMID: 11451947 PMID: 9312068 STATE_TRANSITION s150 s152 0.3333333333333339,-8.881784197001252E-15 0.6666666666666679,-1.7763568394002505E-14 a229 a231 a226 active MKK7: PMID: 12624093 PMID: 9836645 PMID: 9384583 PMID: 9405446 PMID: 9312068 STATE_TRANSITION s152 s151 0.3333333333333339,0.0 0.6666666666666643,3.552713678800501E-15 a231 a230 a228 GTP+Ras: PMID: 11023813 PMID: 14663478 PMID: 12006650 PMID: 10740269 PMID: 8503013 PMID: 12446733 TRANSPORT s153 s154 0.3333333333333339,-1.5987211554602254E-14 0.6666666666666661,-2.8421709430404007E-14 a232 a233 a112 pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac/Cdc42: PMID: 12456688 PMID: 8385802 PMID: 7624324 STATE_TRANSITION s158 s159 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a238 a239 a214 a236 pl.m.Raf-1: PMID: 11023813 PMID: 1322500 PMID: 1326789 PMID: 8393135 MEKK1@GTP+Rac1/Cdc42: PMID: 8385802 PMID: 7624324 STATE_TRANSITION s160 s161 0.33333333333333215,0.0 0.5053913993048011,0.0015582151435875602 a240