2.2 SQUARE inside PROTEIN p0 inside PROTEIN p1 inside SIMPLE_MOLECULE Estrone inside SIMPLE_MOLECULE _space_2_minus_Hydroxyestradiol_minus_17beta inside SIMPLE_MOLECULE _space_2_minus_Methoxyestradiol_minus_17beta inside SIMPLE_MOLECULE Estrone_space_3_minus_sulfate STATE_TRANSITION _space_2_minus_Hydroxyestradiol_minus_17beta _space_2_minus_Methoxyestradiol_minus_17beta c1 c2 STATE_TRANSITION Estrone_space_3_minus_sulfate Estrone c3 c0