2.2 SQUARE inside PROTEIN p0 inside PROTEIN p1 inside SIMPLE_MOLECULE Pyruvate inside SIMPLE_MOLECULE Succinate inside SIMPLE_MOLECULE Thiamin_space_diphosphate inside SIMPLE_MOLECULE _space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate inside SIMPLE_MOLECULE Fumarate STATE_TRANSITION Succinate Fumarate c1 c4 STATE_TRANSITION Pyruvate _space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate c0 c2 c3