<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2"
      xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner">
	<model id="mma00100" name="mma00100">
		<annotation>
			<celldesigner:modelVersion>2.2</celldesigner:modelVersion>
			<celldesigner:modelDisplay sizeX="1044" sizeY="1158"/>
			<celldesigner:listOfCompartmentAliases>
				<celldesigner:compartmentAlias id="ca1" compartment="uVol">
					<celldesigner:class>SQUARE</celldesigner:class>
					<celldesigner:bounds x="10.0" y="10.0" w="1024" h="1138" />
				</celldesigner:compartmentAlias>
			</celldesigner:listOfCompartmentAliases>
			<celldesigner:listOfSpeciesAliases>
				<celldesigner:speciesAlias id="e0" species="geranyltranstransferase" compartmentAlias="ca1">
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				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e1" species="isopentenyl_minus_diphosphate_space__delta__minus_isomerase" compartmentAlias="ca1">
					<celldesigner:bounds x="174" y="277" w="273" h="15.0"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e2" species="hydroxymethylglutaryl_minus_CoA_space_reductase_space__space_NADPH_space_" compartmentAlias="ca1">
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				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e3" species="dimethylallyltranstransferase" compartmentAlias="ca1">
					<celldesigner:bounds x="177" y="356" w="232" h="15.0"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e4" species="mevalonate_space_kinase" compartmentAlias="ca1">
					<celldesigner:bounds x="509" y="274" w="136" h="15.0"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e5" species="NAD_space_P_space_H_space_dehydrogenase_space__space_quinone_space_" compartmentAlias="ca1">
					<celldesigner:bounds x="659" y="381" w="217" h="15.0"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e6" species="geranyltranstransferase" compartmentAlias="ca1">
					<celldesigner:bounds x="130" y="356" w="184" h="15.0"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="e7" species="dimethylallyltranstransferase" compartmentAlias="ca1">
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				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c0" species="trans_space_trans_minus_Farnesyl_space_diphosphate" compartmentAlias="ca1">
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				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c1" species="Vitamin_space_K" compartmentAlias="ca1">
					<celldesigner:bounds x="624" y="356" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c2" species="_space_R_space__minus_Mevalonate" compartmentAlias="ca1">
					<celldesigner:bounds x="580" y="284" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c3" species="Reduced_space_Vitamin_space_K" compartmentAlias="ca1">
					<celldesigner:bounds x="725" y="389" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c4" species="Isopentenyl_space_diphosphate" compartmentAlias="ca1">
					<celldesigner:bounds x="242" y="286" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c5" species="Geranyl_space_diphosphate" compartmentAlias="ca1">
					<celldesigner:bounds x="152" y="495" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c6" species="_space_R_space__minus_5_minus_Phosphomevalonate" compartmentAlias="ca1">
					<celldesigner:bounds x="469" y="284" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c7" species="_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA" compartmentAlias="ca1">
					<celldesigner:bounds x="686" y="285" w="54" h="18"/>
				</celldesigner:speciesAlias>
				<celldesigner:speciesAlias id="c8" species="Dimethylallyl_space_diphosphate" compartmentAlias="ca1">
					<celldesigner:bounds x="152" y="286" w="54" h="18"/>
				</celldesigner:speciesAlias>
			</celldesigner:listOfSpeciesAliases>
			<celldesigner:listOfProteins>
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				</celldesigner:protein>
				<celldesigner:protein id="p1" type="GENERIC" name="isopentenyl_minus_diphosphate_space__delta__minus_isomerase">
				</celldesigner:protein>
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				</celldesigner:protein>
				<celldesigner:protein id="p3" type="GENERIC" name="dimethylallyltranstransferase">
				</celldesigner:protein>
				<celldesigner:protein id="p4" type="GENERIC" name="mevalonate_space_kinase">
				</celldesigner:protein>
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				</celldesigner:protein>
			</celldesigner:listOfProteins>
		</annotation>
		<listOfCompartments>
			<compartment id="default" name="default" />
			<compartment id="uVol" name="uVol" outside="default" />
		</listOfCompartments>
		<listOfSpecies>
			<species id="geranyltranstransferase" name="geranyltranstransferase" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p0</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R02003"/>
						<celldesigner:catalyzed reaction="R01658"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="isopentenyl_minus_diphosphate_space__delta__minus_isomerase" name="isopentenyl-diphosphate delta-isomerase" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p1</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R01123"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="hydroxymethylglutaryl_minus_CoA_space_reductase_space__space_NADPH_space_" name="hydroxymethylglutaryl-CoA reductase (NADPH)" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p2</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R02082"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="dimethylallyltranstransferase" name="dimethylallyltranstransferase" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p3</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R02003"/>
						<celldesigner:catalyzed reaction="R01658"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="mevalonate_space_kinase" name="mevalonate kinase" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p4</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R02245"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="NAD_space_P_space_H_space_dehydrogenase_space__space_quinone_space_" name="NAD(P)H dehydrogenase (quinone)" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>PROTEIN</celldesigner:class>
						<celldesigner:proteinReference>p5</celldesigner:proteinReference>
					</celldesigner:speciesIdentity>
					<celldesigner:listOfCatalyzedReactions>
						<celldesigner:catalyzed reaction="R03643"/>
					</celldesigner:listOfCatalyzedReactions>
				</annotation>
			</species>
			<species id="trans_space_trans_minus_Farnesyl_space_diphosphate" name="trans,trans-Farnesyl diphosphate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>trans_space_trans_minus_Farnesyl_space_diphosphate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="Vitamin_space_K" name="Vitamin K" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>Vitamin_space_K</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="_space_R_space__minus_Mevalonate" name="(R)-Mevalonate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>_space_R_space__minus_Mevalonate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="Reduced_space_Vitamin_space_K" name="Reduced Vitamin K" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>Reduced_space_Vitamin_space_K</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="Isopentenyl_space_diphosphate" name="Isopentenyl diphosphate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>Isopentenyl_space_diphosphate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="Geranyl_space_diphosphate" name="Geranyl diphosphate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>Geranyl_space_diphosphate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="_space_R_space__minus_5_minus_Phosphomevalonate" name="(R)-5-Phosphomevalonate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>_space_R_space__minus_5_minus_Phosphomevalonate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA" name="(S)-3-Hydroxy-3-methylglutaryl-CoA" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
			<species id="Dimethylallyl_space_diphosphate" name="Dimethylallyl diphosphate" compartment="uVol" initialAmount="0.0">
				<annotation>
					<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
					<celldesigner:speciesIdentity>
						<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
						<celldesigner:name>Dimethylallyl_space_diphosphate</celldesigner:name>
					</celldesigner:speciesIdentity>
				</annotation>
			</species>
		</listOfSpecies>
		<listOfReactions>
			<reaction id="R02082" name="R02082" reversible="false">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA</celldesigner:baseReactants>
					<celldesigner:baseProducts>_space_R_space__minus_Mevalonate</celldesigner:baseProducts>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="hydroxymethylglutaryl_minus_CoA_space_reductase_space__space_NADPH_space_" aliases="e2"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA">
						<annotation>
							<celldesigner:alias>c7</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="_space_R_space__minus_Mevalonate">
						<annotation>
							<celldesigner:alias>c2</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="hydroxymethylglutaryl_minus_CoA_space_reductase_space__space_NADPH_space_"/>
				</listOfModifiers>
			</reaction>
			<reaction id="R02245" name="R02245" reversible="false">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>_space_R_space__minus_Mevalonate</celldesigner:baseReactants>
					<celldesigner:baseProducts>_space_R_space__minus_5_minus_Phosphomevalonate</celldesigner:baseProducts>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="mevalonate_space_kinase" aliases="e4"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="_space_R_space__minus_Mevalonate">
						<annotation>
							<celldesigner:alias>c2</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="_space_R_space__minus_5_minus_Phosphomevalonate">
						<annotation>
							<celldesigner:alias>c6</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="mevalonate_space_kinase"/>
				</listOfModifiers>
			</reaction>
			<reaction id="R02003" name="R02003" reversible="false">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>Geranyl_space_diphosphate</celldesigner:baseReactants>
					<celldesigner:baseProducts>trans_space_trans_minus_Farnesyl_space_diphosphate</celldesigner:baseProducts>
					<celldesigner:listOfReactantLinks>
						<celldesigner:reactantLink reactant="Isopentenyl_space_diphosphate" alias="c4"/>
					</celldesigner:listOfReactantLinks>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="geranyltranstransferase" aliases="e0"/>
						<celldesigner:modification type="CATALYSIS" modifiers="dimethylallyltranstransferase" aliases="e7"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="Geranyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c5</celldesigner:alias>
						</annotation>
					</speciesReference>
					<speciesReference species="Isopentenyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c4</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="trans_space_trans_minus_Farnesyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c0</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="geranyltranstransferase"/>
					<modifierSpeciesReference species="dimethylallyltranstransferase"/>
				</listOfModifiers>
			</reaction>
			<reaction id="R01123" name="R01123" reversible="true">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>Isopentenyl_space_diphosphate</celldesigner:baseReactants>
					<celldesigner:baseProducts>Dimethylallyl_space_diphosphate</celldesigner:baseProducts>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="isopentenyl_minus_diphosphate_space__delta__minus_isomerase" aliases="e1"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="Isopentenyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c4</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="Dimethylallyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c8</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="isopentenyl_minus_diphosphate_space__delta__minus_isomerase"/>
				</listOfModifiers>
			</reaction>
			<reaction id="R01658" name="R01658" reversible="false">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>Dimethylallyl_space_diphosphate</celldesigner:baseReactants>
					<celldesigner:baseProducts>Geranyl_space_diphosphate</celldesigner:baseProducts>
					<celldesigner:listOfReactantLinks>
						<celldesigner:reactantLink reactant="Isopentenyl_space_diphosphate" alias="c4"/>
					</celldesigner:listOfReactantLinks>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="geranyltranstransferase" aliases="e6"/>
						<celldesigner:modification type="CATALYSIS" modifiers="dimethylallyltranstransferase" aliases="e3"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="Dimethylallyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c8</celldesigner:alias>
						</annotation>
					</speciesReference>
					<speciesReference species="Isopentenyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c4</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="Geranyl_space_diphosphate">
						<annotation>
							<celldesigner:alias>c5</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="geranyltranstransferase"/>
					<modifierSpeciesReference species="dimethylallyltranstransferase"/>
				</listOfModifiers>
			</reaction>
			<reaction id="R03643" name="R03643" reversible="false">
				<annotation>
					<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
					<celldesigner:baseReactants>Reduced_space_Vitamin_space_K</celldesigner:baseReactants>
					<celldesigner:baseProducts>Vitamin_space_K</celldesigner:baseProducts>
					<celldesigner:listOfModification>
						<celldesigner:modification type="CATALYSIS" modifiers="NAD_space_P_space_H_space_dehydrogenase_space__space_quinone_space_" aliases="e5"/>
					</celldesigner:listOfModification>
				</annotation>
				<listOfReactants>
					<speciesReference species="Reduced_space_Vitamin_space_K">
						<annotation>
							<celldesigner:alias>c3</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="Vitamin_space_K">
						<annotation>
							<celldesigner:alias>c1</celldesigner:alias>
						</annotation>
					</speciesReference>
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="NAD_space_P_space_H_space_dehydrogenase_space__space_quinone_space_"/>
				</listOfModifiers>
			</reaction>
		</listOfReactions>
	</model>
</sbml>
