2.2 SQUARE inside PROTEIN p0 inside SIMPLE_MOLECULE Biotinyl_minus_5_space__minus_AMP inside SIMPLE_MOLECULE Biotin inside SIMPLE_MOLECULE Holo_minus__space_carboxylase_space_ STATE_TRANSITION Biotinyl_minus_5_space__minus_AMP Holo_minus__space_carboxylase_space_ c0 c2 STATE_TRANSITION Biotin Biotinyl_minus_5_space__minus_AMP c1 c0