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| ADIT1 ADIT Postdoctorial position |
ADIT1 ADIT Postdoctorial position
Siena Biotech has an open position funded by ADIT (an integrated project funded by the EU within its 6th Framework Programme) and is looking for highly motivated individual interested in working in a multidisciplinary and international environment. For this position good English language skills are necessary.
The goal of ADIT, which comprises eight European partner institutions, is the design of small molecule therapeutics for the treatment of Alzheimer's disease based on the discovery of innovative drug targets. The project is funded for 5 years and coordinated by Siena Biotech.
Further information can be found at www.aditproject.org.
- Postdoctoral position in Bioinformatics/Proteomics (Job Code ADIT
1) Responsibilities: Support of the ADIT drug discovery process in Alzheimer's disease (AD) at the target identification stage. Two aspects are covered: 1) Support the analysis of data obtained from differential mass spectrometry experiments in order to identify proteins involved in molecular mechanisms leading to AD. This requires the ability to deal with large amounts of data, a reasonable knowledge of mass spectrometry data generation as well as proven expertise in data analyses methodologies (ion-map comparison, MS/MS) and implementation.
2) Curation of the AD pathway employing information generated from in-house proteomics analysis and from public data sources, in collaboration with Alzheimer's disease experts and bioinformaticians. To a large degree the work will revolve around the biological understanding of disease mechanisms in AD, thus bringing together published results with in-house experimental data.
Requirements: Ph.D. in bioinformatics or a related field with expertise in mass spectrometry applied in proteomics. Ability and interest in elucidating biomolecular pathway mechanisms. Experience with the usage of text mining, sequence alignments, micro-array data analysis and related bioinformatics skills would be a plus.
www.sienabiotech.com
This position is initially funded for two years.
posted 2007/3/22 |
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| Senior Research Scientist - Plant Systems Biology |
Senior Research Scientist - Plant Systems Biology
Mendel Biotechnology, Inc., invites applications for a Senior Research Scientist position in Plant Systems Biology. The candidate needs to have expertise in both computer science, statistics or mathematics, and biology. Strong computer programming capabilities are required, as are proven skills analyzing large sets of gene expression/microarray data as
well as DNA and protein sequences. The successful applicant will design & implement tools for processing, analyzing and visualizing large datasets, including using mathematical models for predicting gene expression network organization and de novo identification of cis-acting promoter regulatory elements. Candidates who have previously worked with plant systems are especially encouraged to apply. Applicants must have a PhD with a minimum of 3 years postdoctoral experience. Strong written and oral communication skills in the English language are considered essential.
Applications, including the names, mailing addresses, and e-mail addresses of at least two references should be submitted to: job71 @ mendelbio.com. More information about Mendel can be found at www.mendelbio.com.
posted 2007/3/13 |
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| Research Assistant to work on systems biology in the mouse |
Research Assistant to work on systems biology in the mouse
ENFIN - European funded project
MRC Mammalian Genetics Unit
Research Opportunity – Mammalian Genetics Unit, Oxfordshire
Starting salary £24,993 per annum
We are seeking a Research Assistant who will be responsible for developing systems biology approaches to the analysis of mouse models relevant to human disease. The project forms part of the EU-funded ENFIN project (http://www.enfin.org) which aims to develop systems biology infrastructure in Europe and will be highly collaborative, involving interactions both with experimental groups within the Unit and with other ENFIN partners. The person appointed will be based in the Bioinformatics Group at Harwell and will have a strong mathematics or mathematical biology background, an interest in biology and the application of mathematics to biological problems, and some computing/programming expertise. There may be opportunities to participate in experimental testing of in silico models as well as computational analysis.
In return, we can offer a competitive salary, 30 days holiday and a generous pension scheme.
See the bioinformatics group website http://informatics.har.mrc.ac.uk/ for more information on current research in the group and http://www.mgu.har.mrc.ac.uk/ for more information on the Unit's research. Please contact John Hancock (j.hancock @ har.mrc.ac.uk) with any questions.
This post is funded by a grant from the EU with a fixed end point of 14 November 2008 with the possibility of extension.
For an application form please email oxford.recruitment @ ssc.mrc.ac.uk or contact Emma Keeble on 01793 301037, quoting reference number 2007-072/MGU ENFIN Research Assistant.
Closing date for applications: 16th March 2007
The MRC is an Equal Opportunities Employer
posted 2007/3/8 |
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| Two post-doctoral positions at the Bioinformatics and Computational Systems Biology |
Two post-doctoral positions are open at the Bioinformatics and Computational Systems Biology Unit, Institut Curie, Paris.
The first position deals with the analysis of promoter regions of genes involved in the transcriptome response to the activation of an oncogene, based on sequence information, transcriptome profiles, and ChIP chip data.
The second position deals with the development and application of statistical techniques for dimension reduction in cancer microarray experiments: independent component analysis and other non-linear methods will be evaluated, applied to different cancer datasets, and the significance of their results assessed.
Mission location:
Bioinformatics and Computational Systems Biology Unit, Institut Curie, Paris Institut Curie is one of the biggest European institutions for research in cancer and patient care with strong and old interdisciplinary traditions. It is located in the center of Paris in both cultural and scientifically rich environment. The Bioinformatics Unit of Institut Curie was created in 2003 and consists in an interdisciplinary team of 25 biologists, mathematicians, statisticians, physicists and computer scientists. One important research direction of the unit is formalizing biological and clinical knowledge about cancer and confronting it with the results of high-throughput experiments (microarrays, molecular interactions, cellular phenotypes ...) being made in the biological laboratories of Institut Curie.
Requirements for candidates:
We expect the candidate to have formation in computational biology, physics, mathematics or computer science. The successful candidate should have experience in modeling molecular mechanisms in biology, especially creating qualitative models. It will be advantageous to be
able to demonstrate some knowledge of basic biological mechanisms involved in cancer (regulation of cell cycle, apoptosis, etc.) and have experience of collaboration with biologists for solving concrete biological problems. Other advantage will be familiarity with standards in Systems Biology (SBML, BioPax) and with existing software for pathway modeling. Programming skills and good knowledge of English both spoken and written are required.
Links:
For more information about the institute:
http://www.curie.fr
For more information about the laboratory:
http://bioinfo.curie.fr
http://bioinfo.curie.fr/sysbio
http://bioinfo.curie.fr/projects/sitcon
The candidates should send a letter of motivation, a CV, reprints of their main publications and references by e-mail to bcsb15 @ curie.fr
posted 2007/3/7 |
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| Researcher / Postdoctoral positions for Systems Biology available |
ERATO-SORST Kitano Symbiotic Systems Project (http://www.symbio.jst.go.jp) has an opening for researcher or post-doctorial fellow to work on systems biology research. The project is funded by Japan Science and Technology Agency as a part of SORST Program and carried out by The Systems Biology Institute.
A position is available for those who are interested in focus areas of the project. Some of research topics include, but are not limited to;
Theoretical Studies: theory of biological robustness, theoretical studies on system-level properties of biological systems, studies to bridge physics, control theory, information theory, and biology.
Computational platform for systems biology; including development of CellDesigner, SBML, and SBGN, application of web 2.0 to biological knowledge accumulation, and other novel ideas on computational platform for systems biology.
Microfluidics for systems biology research.
Cancer Systems Biology: diagnosis, robustness control, and drug and therapy strategy design based on cancer robustness framework.
Modeling signal transduction and cell cycle.
Extensive collaborations with other institutions in Japan and around the world are expected.
The position is based on annual contract and for approximately two years until the end of the current funded project. The office and laboratory is in Tokyo . Salary range and benefits is based on JST scale.
For details, please contact Hiroaki Kitano (job at sbi.jp) with your research interest, major papers, and CV. Title of e-mail should be "SORST POSITION: your name"
posted 2006/11/08 |
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| Post-Doctoral Position in computational methods for systems genetics |
The University of Tennessee and Oak Ridge National Laboratory announce a post-doctoral fellowship in computational methods for systems genetics. This position, funded by the U.S. Department of Energy, provides up to three years of support and offers the successful applicant a unique opportunity to become a member of the UT-ORNL research program in computational biology for mammalian genetics.
Recent PhD graduates with skills in genomics, high-throughput biological data analysis, combinatorial and graph algorithms, multivariate statistics, mathematical modeling, or some combination thereof are especially encouraged to apply.
Potential candidates should direct inquiries to Mike Langston (langston @ cs.utk.edu) or Brynn Voy (voybh @ ornl.gov).
posted 2007/2/6 |
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| PostDoctorial Fellow Position in Systems Biology / Computational Biology |
BETH ISRAEL DEACONESS MEDICAL CENTER/HARVARD MEDICAL SCHOOL
The BIDMC Genomic Center is recruiting a research fellow in Systems Biology / Computational Biology. The BIDMC Genomic Center has an interdisciplinary team of highly experienced investigators for bioinformatics, genomics, proteomics and systems biology. The job provides opportunities to interested candidates to perform excellent research with specific focus on using informatics, statistical, and computational techniques to solve disease biology problems through biomarker discovery, drug discovery, and clinical research translations. We are looking for a researcher to join our team in the development of improved methods for Systems Biology, Interactive Networks and Genomic and Proteomic analysis.
Successful candidates should hold a MD, MD PhD, Ph.D or MSc in Computational Biology /Bioinformatics /Computer Science/Biochemistry/ Mathematics/Engineering/ Physics or Statistics. The position requires a strong background in algorithms and statistics, data management and mining, and machine learning. The candidate should have prior experience of work in systems biology and its stochastic computing, integrative modeling (using strong Bayesian network, HMM, etc.) and computational aspects. Candidates with prior experience in proteome informatics are desirable. Candidates should have excellent programming skills and experience in C/ C++/ Java/ Perl/ Python and R. Highly motivated and creative candidates with excellent record of publications in peer-reviewed journals are encouraged to apply. The candidate is expected to have outstanding personal initiative and be able to work effectively as part of a team.
Applicants must be Permanent residents/Citizens of United States due to funding restrictions. Candidates meeting the requirements above are strongly encouraged to apply before March 31, 2007.
Candidates who are willing to work in an exciting environment on the cutting edge of systems biology, genomics, proteomics and translational medicine are encouraged to apply. Please send a CV, a brief description of previous research and the names of three references to the address below.
TOWIA A. LIBERMANN, PH.D.
Associate Professor of Medicine
BIDMC Genomics Center and Dana Farber/Harvard Cancer Center Cancer Proteomics Core
Beth Israel Deaconess Medical Center
Harvard Institutes of Medicine
2nd Floor
4 Blackfan Circle
posted 2007/1/18 |
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| BioPharmaceutical Applications Engineer for The MathWorks (MATLAB) |
BioPharmaceutical Applications Engineer for The MathWorks (MATLAB)
The MathWorks supports leading biotech and pharmaceutical companies and universities with cutting edge software tools that help streamline, automate, and advance computational biology research. The MathWorks works with scientists and computational biologists to help realize the advantage of computational methods over traditional biology research. Areas of application include, but are not limited to bioinformatics, systems biology, and medical imaging.
The primary responsibility of this highly visible position is to enable the sales organization to effectively support customers who can benefit by using MATLAB and SimBiology to simulate, model, and analyze biochemical pathways. This application engineer will also be responsible for supporting the broad range of applications of The MathWorks software within the BioPharmaceutical industrial and academic communities. The BioPharmaceutical Application Engineer will work directly with MATLAB users to address technical issues regarding the adoption of The MathWorks software. This requires a deep understanding of both The MathWorks software and of the customers' applications.
As a core member of the SimBiology team at The MathWorks, the BioPharmaceutical Applications Engineer will work closely with Development and Marketing to influence product direction and positioning.
The successful candidate for this position will have a desire and ability to share his or her passion for the benefits of biological systems modeling with MATLAB and SimBiology.
The position is based out of The MathWorks headquarters in Natick, Massachusetts (a Boston suburb). Interested candidates can learn more about the position and apply for it here: http://www.mathworks.com/company/jobs/opportunities/Job5233.html
posted 2007/1/5 |
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| Post Doctoral Research Fellow in Evolutionary Systems Biology |
A postdoctoral research position is available in Systems Biology. Applicants should have an interdisciplinary research background in any of several areas of evolutionary, molecular, or systems biology, and hold (or be about to receive) a PhD. Areas of interest include but not limited to: Biological network evolution, gene-networks of complex traits such as aging, cancer, and neuropsychiatric diseases. See http://www.bergmanlab.org
The position is available immediately and for the duration of 1-3 years; Salary (in the range of $37K to $40K, plus benefits) will be commensurate with experience. EOE.
Please send or email (application2007@bergmanlab.org) your CV, publications list, and three letters of recommendation to:
Aviv Bergman, PhD
Professor
Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Bronx, NY 10461, USA
posted 2006/12/15 |
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| Postdoctorial Position 'Theoretical Systems Biology' in Dresden, Germany |
Postdoctorial Position 'Theoretical Systems Biology' in Dresden, Germany
Center for Information Services and High Performance Computing,
Technical University of Dresden, Germany
Applications from highly qualified candidates are invited for a two-year full postdoctoral fellow position in Theoretical Systems Biology. The goal is to unravel fundamental principles of receptor trafficking and growth factor signaling in hepatocytes with a focus on TGFbeta. As one example, the cellular context-specific role of TGFbeta shall be understood through the development and analysis of spatio-temporal mathematical models in conjunction with fluorescence video-microscopy data and RNAi screens available from the in-town experimental partner.
The successful candidate will conduct her/his research within the systems biology network HepatoSys complementing this project with a broad spectrum of experimental and theoretical tools.
The ideal candidate holds a Ph.D. in physics, mathematics or biology (or similar), has demonstrated expertise in mathematical biology, network analysis, stochastic methods and has an interest in molecular cell biology and biophysics. Strong communication skills are a benefit for the close collaboration with experimental cell biologists.
The Center for Information Services and High Performance Computing, Technical University of Dresden, Germany, hosts a department focusing on the mathematical modelling of biological systems (head: Andreas Deutsch), in which the envisaged research will be conducted. Dresden campus offers a multidisciplinary research landscape unique in Europe. The city of Dresden is situated in the Elbe valley that is also rich in culture and natural beauty.
The position is available immediately. Deadline for applications (by email, including two letters of recommendation): December 20, 2006.
Contact:
Andreas Deutsch, andreas.deutsch@tu-dresden.de
and for general information:
http://rcswww.urz.tu-dresden.de/~imc
http://endosys.mpi-cbg.de
posted 2006/12/10 |
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| Senior systems biologist/Systems biologist position available |
Senior systems biologist/Systems biologist position available.
The Centre for Computational Systems Biology
WA State Centre of Excellence, based at the University of Western Australia, Perth
Senior systems biologist (Research Fellow - Ref: 1572)
Systems biologist (Research Associate – Ref: 1573)
http://www.plantenergy.uwa.edu.au/webpages/opportunities/employment_uwa.html
The Office of Science, Technology and Innovation of the Department of Industry and Resources within the Government of Western Australia is establishing a State Centre of Excellence in Computational Systems Biology. The Centre will be based in Perth and will work closely with the ARC Centre of Excellence in Plant Energy Biology (CoE PEB), a joint venture between The University of Western Australia, the Australian National University and the University of Sydney.
CoE PEB is an ambitious new enterprise incorporating seven teams totalling more than 70 researchers at the three universities, with the majority of the staff being based at UWA in Perth. The principal aim of the Centre is the discovery and characterisation of molecular components and control mechanisms that drive energy metabolism in plant cells. The research is primarily based on cutting-edge functional genomics studies in the model plant Arabidopsis thaliana. The long-term aim of the Centre is to gain sufficient understanding of plant energy metabolism to be able to rationally design plants for optimal use in agriculture and the environment.
The Centre of Excellence for Computational Systems Biology (CoE CSB) will involve a dedicated team of bioinformaticists/mathematicians/statisticians who will analyse the transcriptomics, proteomics and metabolomics data produced by the CoE PEB researchers in order to build models of plant energy metabolism. The goal will be to discover regulatory networks controlling these processes. A wider aim of the CoE PEB will be to promote the understanding and uptake of modern systems orientated approaches within biotech research and industry in WA, both in plant and animal sciences.
The positions will be based alongside the CoE PEB headquarters in UWA's new Molecular and Chemical Sciences building. The positions will involve tight collaboration with CoE PEB researchers and close links to nearby computing centres such as the Western Australian Supercomputing Program based at UWA and the Centre for Comparative Genomics based at Murdoch University.
To discuss or clarify any aspects of the positions please contact, by email, Professor Ian Small, iansmall @ cyllene.uwa.edu.au.
CLOSING DATE: Friday, 5 January 2007
APPLICATION DETAILS: For copies of the selection criteria please access the website http://jobs.uwa.edu.au/. Applicants must address the selection criteria. Written applications quoting the reference number, personal contact details, qualifications and experience, along with contact details of three referees should be sent to Director, Human Resources, The University of Western Australia, M350, 35 Stirling Highway, Crawley WA 6009 or emailed to jobs @ uwa.edu.au by the closing date.
posted 2006/11/22 |
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| Post-doc in Computational Biology |
Post-doc in Computational Biology : Qualitative modeling of molecular pathways involved in the Ewing inducible cellular model.
A two years post-doctoral position starting in 2007 is open at the Institute of Mathematical Research in Rennes (France) for Computational Systems Biology of Cancer. This position is created to support the participation of IRMAR to the interdisciplinary project SITCON (Modeling signal transduction induced by a chimeric oncogene) in collaboration with the Curie Institute in Paris and with the computer science laboratory IRISA in Rennes (Symbiose team). The role of this post-doc is to apply and to extend existent qualitative approaches to heterogeneous data in cancer. These approaches use qualitative equations, graph theoretical methods and polynomial coding in finite fields.
Requirements for candidates: We expect the candidate to have formation in mathematics, physics or computer science. Experience in modeling molecular mechanisms in biology will be appreciated.
Job location: The post doc will be affiliated to the Institute for Mathematical Research in Rennes.
Application: Applicants should submit a brief letter of motivation a detailed CV with publication list, and the names of at least three referees by e-mail (with subject 'post-doc ANR SITCON'), to ovidiu.radulescu@univ-rennes1.fr. The applications will be received from November 1, 2006 and until a convenient candidate is found.
Starting date: as soon as possible, not later than September 2007.
Links:
about the job:
http://perso.univ-rennes1.fr/ovidiu.radulescu/stages/postdoc/postdoc.html
about the project:
http://perso.univ-rennes1.fr/ovidiu.radulescu/EWING.html
posted 2006/11/21 |
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| Postdoctoral and PhD position - Ghent University (Belgium) |
Postdoctoral and PhD position - Ghent University (Belgium)
The Research Group Bioinformatics and Evolutionary Genomics of the Department of Plant Systems Biology at Ghent University (Belgium) is currently looking for exceptional candidates to fill one postdoctoral and one PhD position.
The research will focus on computational systems biology, primarily through the modeling and analysis of biological networks, and is part of a newly founded interdisciplinary research initiative on top down systems biology, involving partners at 3 Flemish universities.
The ideal candidate will have a background in ioinformatics with a preference for algorithms and statistics, or a background in mathematics, physics, engineering or computer science with a strong interest in biological applications, and have sufficient programming experience in Matlab, Java, C++ or similar languages. Applicants must have an advanced knowledge of English, which is the language used for all departmental communications.
Interested candidates should send a curriculum vitae including list of publications, a motivation letter and the names of three referees by email to Prof. Yves Van de Peer ( yves.vandepeer @ psb.ugent.be).
The Bioinformatics and Evolutionary Genomics group is a young and dynamic research group of about 25 people carrying out research on the structure and evolution of genes, gene families, genomes and genetic networks. The Department of Plant Systems Biology belongs to the Flanders Interuniversity Institute for Biotechnology and Ghent University, and is located in Ghent (Flanders, Belgium), a beautiful and welcoming city of 230,000 inhabitants, with a large student population and a dynamic cultural scene. It is only 30 minutes from Brussels and about two hours from Amsterdam, London and Paris.
Websites for more information:
http://bioinformatics.psb.ugent.be/
http://www.psb.ugent.be/
http://www.vib.be/
http://www.ugent.be/
http://www.visitgent.be/
Contact:
Prof. Yves Van de Peer
VIB / Ghent University
Bioinformatics & Evolutionary Genomics
Technologiepark 927
B-9052 Gent
BELGIUM
+ 32 (0) 9 33 13 807 (phone)
+ 32 (0) 9 33 13 809 (fax)
yves.vandepeer @ psb.ugent.be
posted 2006/11/20 |
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| Postdoc position available January 2007 (RefPD2) |
*Universitat Pompeu Fabra*
Departament de Ciències Experimentals i de la Salut
The Computational Biochemistry and Biophysics Laboratory (CBBL) at the Research Unit on Biomedical Informatics (GRIB) is seeking a highly motivated postdoctoral researcher who has a deep interest in mathematical and computational developments in the broad field of systems biology related to its biomedical application.
The candidate will participate in the framework of the FP6 EC-funded STREP project BioBridge. The project aims to create tools for interfacing omics and clinical data for complex diseases, like COPD, through simulation. His/her tasks will involve the further development of our software tool for the study of large kinetic data, ByoDyn . The profile of the candidate is wide, including researchers coming from engineering fields, but deep knowledge of Python and/or Modelica object oriented programming and on bindings to other programming languages is required. Experience on code parallelization is a plus. The work will be related to the implementation of parameter estimation and optimal design tools for metabolic networks modelling. MSc holders with appropriate CVs will also be considered.
Although funding is guaranted for 2 years, own initiatives to obtain an external fellowship will be strongly supported.
The GRIB/UPF is part of the new Barcelona Biomedical Research Park which, with a privileged location on the shoreline of the Mediterranean sea, constitutes one of the most exciting interdisciplinary research centres in South Europe in one of the fastest growing biomedical research regions in the area.
To apply, please, send by e-mail a statement of interest, your CV and the name of two referees to whom we may contact for details. Please, indicate /Ref PD2/ in your application.
Jordi Villà i Freixa
Computational Biochemistry and Biophysics lab
Research Unit on Biomedical Informatics (GRIB) of IMIM/UPF
Parc de Recerca Biomèdica de Barcelona (PRBB)
C/ Doctor Aiguader, 88; 08003 Barcelona (Spain)
Tel: +34 93 316 0504 (1504) // Fax: +34 93 316 0550
e-mail: jvilla @ imim.es http://diana.imim.es
posted 2006/11/20 |
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| Postdoctorial Fellow - Systems Biology |
Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co. Inc., develops and implements technologies that will improve drug discovery. The company's leading-edge genomic research and data analysis efforts focus on how medical compounds affect biology, enabling more accurate selection of drug targets and more efficient drug development.
A postdoctoral position is available at Rosetta that will focus on developing and applying computational systems biology approaches to elucidate and utilize biological pathways in drug discovery. Research topics include developing and applying approaches to
Ascertain the mechanisms and pathways underlying gene and protein expression patterns.
Predict effects of perturbations such as siRNA knockdown or compound interactions using protein-protein interaction and/or gene regulatory networks models.
Identify mechanism-based biomarkers using high throughput genomic data and clinical endpoints.
This postdoctoral position will be hosted by the Informatics department at Rosetta and is jointly sponsored by Robert Gentleman, Fred Hutchinson Cancer Research Center Program in Computational Biology. Comprehensive pathway databases, the world's largest expression data respository, RNAi technologies, access to clincal samples with rich clinicial data, collaborative interactions with a critical mass of informatics and bioinformatics scientists, and state of the art computational facilities are some of the resources that will be available to the successful candidates.
Qualifications include: Ph.D. in bioinformatics or related field with solid background in molecular biology, computer science, and statistics. Solid training in data analysis algorithms is essential. Background in oncology or metabolic disease is desirable, as is experience in systems biology, pathways or network bioinformatics. Applicants should have demonstrated excellence in one or more of these areas, including a strong publication record.
To be considered for this position, please visit our career site at www.rii.com/jobs under Postdoctoral Opportunities to submit your resume. Rosetta is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.
posted 2006/8/14 |
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| Postdoctoral Position in Systems Biology - October 2006 (earliest) |
Systems Biology of Apoptotic Cell Death Signaling Networks
Applications are invited for a Postdoctoral position in Systems Biology (initially for three years) in the Department of Physiology and Medical Physics/RCSI, Dublin, Ireland. The position is funded by the Health Research Board Ireland (HRB).
Candidates should have a background in systems biology, computational biology, biophysics or applied mathematics, and be experienced in numerical analysis/programming (e.g. C++, MATLAB, Mathematica). Excellent written and communication skills and a high level of motivation and commitment are required. The institute is located in the heart of Dublin city and offers an international and interdisciplinary working environment spanning the fields of systems biology, cancer and molecular biology, biophysics, and mathematics.
Apoptotic cell death is regulated by complex signalling networks spanning several compartments within living cells. Impaired apoptosis can result in developmental disorders and cancer. In an industry collaboration with SIEMENS (Medical Division) the applicant will translate biological systems into novel computational models that allow the spatiotemporal and quantitative prediction of signalling events, and the identification of key regulatory factors or threshold mechanisms deciding on apoptotic cell death. The applicant will work interactively with the experimentalists to discuss model validity and restrictions. Generated models will qualitatively and quantitatively be validated by experimentalists measuring the real time kinetics of key signalling events within living cells.
Applications should include CV and names and addresses of two referees and be sent (preferably by e-mail) to:
Dr. rer. nat. Markus Rehm
Lecturer in Physiology and Biophysics
Department of Physiology and Medical Physics
Royal College of Surgeons in Ireland
York Street Building
Dublin 2
Ireland
email: mrehm at rcsi . ie
[PDF]
posted 2006/8/14 |
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| Lectureship in Complex and Disordered Systems in the Disordered Systems group of the Department of Mathematics |
Applications are invited for a Lectureship in Complex and Disordered Systems, in the Disordered Systems group of the Department of Mathematics, to be taken up with effect from January 2007 or as soon as possible thereafter.
The successful candidate will expand and enhance the research spectrum of the Disordered Systems group. In particular we are looking for a candidate whose research expertise falls within the statistical mechanics of disordered and complex systems (equilibrium and non-equilibrium), and its applications to e.g. glassy physics (structural, spin and quantum glasses), soft condensed matter (polymers, glassy rheology, polydispersity), complex networks, proteins and their interactions, biophysics, econophysics, machine learning, or statistical inference.
The successful candidate will be expected to contribute to the teaching of the interdisciplinary MSc course in Information Processing and Neural Networks, and to other applied mathematics courses.
We are looking for candidates with a proven research track record appropriate for appointment to the above post. Applicants will be expected to hold a PhD in Applied Mathematics or Theoretical Physics and have postdoctoral experience in the statistical mechanics of complex and disordered systems. They will have demonstrated, through published work in highly rated and high-calibre journals, the potential to develop an international reputation in their research areas. They will preferably have worked with research students and have some experience of teaching in a university environment.
The full details and application pack can be downloaded from
http://www.mth.kcl.ac.uk/research/dsnn/LectureshipDisorderedSystems.doc
The closing date for applications is 25 August 2006 so applications should be submitted as soon as possible.
posted 2006/8/3 |
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| Senior Research Scientist - Network/Pathway Analyst |
Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co. Inc., develops and implements technologies that will improve drug discovery. The company's leading-edge genomic research and data analysis efforts focus on how medical compounds affect biology, enabling more accurate selection of drug targets and more efficient drug development.
We are currently seeking a Senior Research Scientist - Network/Pathway Analyst who will work in a multi-discipline team and contribute significantly to our efforts to systematically study complex human diseases through the integration of genetics, genomics, gene expression, transcription factor binding arrays, RNAi, clinical end-points, protein-protein interaction, literature data, etc. The goal of the research is to identify causal relationships between gene-gene or gene-clinical traits and represent them in networks or probabilistic graphic models. Such causal networks (PMIDs 15237224, 15965457, 16126366, 16200066) will be used to elucidate disease or drug mechanism and aid target discovery/target prioritization. The person in this position will be responsible for developing novel methods to integrate diverse data sources, comparing different networks (human and mouse, or liver and adipose) and identifying common features among networks or distinct pathways between normal networks and disease specific networks.
Qualifications: Prefer a Ph.D., but will consider a Master's degree in physics, mathematics, statistics, computer science, electronic engineering, or bioinformatics with 3 years' experience integrating large diverse data sets using graphic models.
To be considered for this position, please visit our career site at www.rii.com to create a profile and submit your resume for Job #SCI002851. Rosetta is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.
posted 2006/7/22 |
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| Post-doctoral position for Computational Systems Biology of Cancer |
A one year post-doctoral position is open at Institut Curie (Paris, France) for Computational Systems Biology of Cancer.
* Mission title: Modeling molecular pathways involved in cancer *
This position is created to support participation of Institut Curie in the European project "European Systems Biology Initiative combating complex diseases". One of the missions of Institut Curie in the project is creating a repository of models of molecular pathways involved in cancer (mainly, signaling pathways, controlling cell cycle and apoptosis). The repository will consist of several existing working pathway models and other models will be created in the duration of the project. The formalism of modeling will be one of the qualitative modeling approaches (Petri Nets, logical discrete formalism, Boolean networks, etc.). The main purpose of the repository will be to confront the existing biological knowledge about cancer with results of high throughput experiments, so one part of the mission will be developing model checking methods.
* Mission location: Bioinformatics and Computational Systems Biology Unit, Institut Curie, Paris, France *
Institut Curie is one of the biggest European institutions for research in cancer with strong and old interdisciplinary traditions. It is located in the center of Paris in both culturally and scientifically rich environment.
The Bioinformatics and Computational Systems Biology Unit of Institut Curie was created in 2003 and consists in an interdisciplinary team of 25 biologists, mathematicians, statisticians, physicists and computer scientists from 10 different nationalities. One important research direction of the unit is formalizing biological knowledge about cancer and confronting it with the results of high-throughput experiments being made in the biological laboratories of Institut Curie.
* Requirements for candidates: *
We expect the candidate to have formation in mathematics, physics or computer science. Successful candidate should have experience in modeling molecular mechanisms in biology, especially creating qualitative models.
It will be advantageous to be able to demonstrate some knowledge of basic biological mechanisms involved in cancer (regulation of cell cycle, apoptosis, etc.) and have experience of collaboration with biologists for solving concrete biological problems.
Another advantage will be familiarity with standards in Systems Biology (SBML, BioPax) and with existing software for pathway modeling.
Programming skills are needed. Good communication skills and good knowledge of English both spoken and written are required.
* Links: *
For more information about the project:
http://pybios.molgen.mpg.de/ESBIC-D
For more information about the institute: http://www.curie.fr For more information about the laboratory: http://bioinfo.curie.fr
* Application: *
Applicants should submit a letter of motivation (with reference BCSB11), a detailed CV with publication list, and the names of at least three referees by e-mail to bcsb11@curie.fr For further information, please contact Emmanuel.Barillot @ curie.fr
posted 2006/7/5 |
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| Post-Doctoral Research Associate position in Systems Biology |
Research Associate in Molecular Systems Biology and Control, Ref: R2583/WEB
Department of Engineering, University of Leicester
R&A1A scale £20,044 to £30,002, Available immediately for 2 years
This post, funded by an EPSRC Platform Grant on Control of
Complex Systems, will involve research on the modelling and analysis of biological control systems at the cellular level. Applicants must have a PhD in a relevant area of Control or Dynamical Systems Theory, Mathematics or Biology. Further particulars and an application form are available at: http://www.le.ac.uk/personnel/jobs/r2583a.html
Closing date: 21 March 2006
posted 2006/3/9 |
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| Professorship of Integrative Systems Biology in The University of Oxford |
The University is committed to developing Systems Approaches across the Biosciences and as part of this commitment it has created a new chair in Integrative Systems Biology to spearhead these approaches across the University. While the chair will be based within the Biochemistry Department, the appointee will be expected to work across Departments and Divisions, bringing together research teams from across the Physical and Biomedical Sciences. The appointment will be from 1 January 2007, or as soon as possible thereafter.
A non-stipendiary fellowship at Merton College is attached to the professorship.
Please see http://www.admin.ox.ac.uk/fp/wd19-016.shtml for full details.
posted 2006/2/10 |
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| Chair in Systems Biology at Centre for Integrative Systems Biology, Impreial College London |
Centre for Integrative Systems Biology
Imperial College London
CHAIR IN SYSTEMS BIOLOGY
Applications are invited for the Chair in Systems Biology, with effect from 1 July 2006 or as soon as possible thereafter.
The post is within the Division of Molecular Biosciences, Faculty of Natural Sciences at Imperial College, based on the South Kensington campus.
The appointee will be the Director of the newly established Imperial College Centre for Integrative Systems Biology (CISBIC), which is supported by BBSRC and EPSRC. CISBIC has an exemplar research programme which is focused around analysis of the innate immune response to bacterial pathogen infection, based on a set of three interlinked projects, each addressing fundamental issues in systems biology and each involving closely interacting teams of biological and numerical researchers. The new Director will be expected to have an outstanding international scientific reputation and an ongoing, innovative research programme that complements this exemplar programme and the systems biology expertise within CISBIC.
The Director will be responsible for coordinating the efforts of a wide range of researchers and must have appropriate skills, experience and background to deliver the specific CSBIC research programme. It is envisaged that the appointee will be addressing fundamental biological questions but could have either an experimental or a theoretical background. A high and proven level of management skills and an ability to foster interdisciplinary interactions both within and external to Imperial College will be required.
Further particulars of this appointment are on:
http://www.imperial.ac.uk/employment/academic/
Closing Date: 28 February 2006
Interview Date: Late April/Early May 2006
Valuing diversity and committed to equality of opportunity.
posted 2006/1/8 |
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| A faculty position within computer science at the University of Texas San Antonio in Bioinformatics / Computational Biology |
THE UNIVERSITY OF TEXAS AT SAN ANTONIO
Faculty Position in Bioinformatics
The Department of Computer Science at The University of Texas at San Antonio invites applications for a tenure/tenure-track position in bioinformatics or computational biology, starting in the fall of 2006. The rank of the position may be at the assistant, associate or full professor level depending on applicant qualifications.
Required qualifications: Candidates must have a Ph.D. or the equivalent in computer science or a related discipline. Candidates must also have a record of research accomplishment in bioinformatics or computational biology with a research focus that is both strongly computational and biological.
Responsibilities: The successful applicant is expected to establish and maintain an extramurally funded research program, and contribute to undergraduate and graduate teaching in computer science. Courses are offered both at the UTSA Downtown Campus or the 1604 campus, and occasionally in the evening. The successful applicant will join an interactive group of researchers in computer science, biology and statistics at UTSA and the nearby UT Health Science Center and participate in the development of new interdisciplinary degree programs in bioinformatics and computational biology.
This position offers the opportunity to join an outstanding and expanding group of scientists in a highly interactive, interdisciplinary research environment supported by state-of-the-art research facilities. Attractive startup packages and access to a variety of shared facilities are available including a Bioinformatics/Computational Core Facility, an Imaging Core Facility, a Proteomics Core Facility, and a Genomics Core Facility which are being collocated in a new $85M building housing biological sciences and engineering.
The Department of Computer Science currently has 24 faculty members and offers B.S., M.S., and Ph.D. degrees supporting a dynamic and growing program with over 500 undergraduate and 100 graduate students. (See http://www.cs.utsa.edu for additional information on the Department of Computer Science and its faculty.)
The University is the largest public university in south Texas serving over 27,000 students. The city of San Antonio has a population of over one million and is known for its rich Hispanic culture, historic attractions, affordable housing, and excellent medical facilities. Substantial computer and biotechnology industry is located in San Antonio and Austin, located 75 miles away. Nearby higher education and research institutions include UT Health Science Center and Southwest Research Institute.
Applicants must submit a signed letter of application that includes an indication of the level of position for which they are applying. Applications must also include a complete dated curriculum vitae (including employment chronology, publications and grants), a statement of research interests, and the names, addresses (postal and e-mail), and telephone numbers of at least three references. Applicants who are not U.S. citizens must state their current Visa and residency status. Screening will begin immediately, and will continue until the position is filled (pending budget approval). The University of Texas at San Antonio is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans, and individuals with disabilities are encouraged to apply. This position is security-sensitive as defined by the Texas Education Code §51.215(c) and Texas Government Code §411.094(a)(2). Applications may be faxed, emailed, or mailed to:
Chair of Bioinformatics Faculty Search Committee
Department of Computer Science
The University of Texas at San Antonio
6900 North Loop 1604 West
San Antonio, TX 78249-0667
bioinfosearch @ cs.utsa.edu
FAX: 210-458-4437
posted 2005/11/30 |
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