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Last updated : 2008/3/15
PhD Student Position in Systems Biology - 2008

PhD Student Position in Systems Biology - 2008
Systems Biology of Apoptotic Cell Death Signaling Networks

Applications are invited for a PhD studentship in Systems Biology in the Department of Physiology and Medical Physics/RCSI, Dublin, Ireland.

Candidates should have a background in computational biology, biophysics, or systems biology, and be experienced in numerical analysis/programming (e.g. C++, MATLAB, Mathematica or others). Good written and communication skills and a high level of motivation and commitment are required. The institute is located in the heart of Dublin city and offers an international and interdisciplinary working environment spanning the fields of systems biology, cancer and molecular biology, biophysics, and medical research.

Apoptotic cell death is regulated by complex signalling networks spanning several compartments within living cells. Impaired apoptosis can result in developmental disorders and cancer. In an industry collaboration with SIEMENS (Medical Division) the student will translate biological systems into novel computational models that allow the spatiotemporal and quantitative prediction of signalling events, and the identification of key regulatory factors or threshold mechanisms deciding on apoptotic cell death.
The applicant will work interactively with the experimentalists to discuss model validity and restrictions. Generated models will qualitatively and quantitatively be validated by experimentalists measuring the real time kinetics of key signalling events within living cells.

Applications should include CV, scans of relevant certificates and names and addresses of two referees and be sent (preferably by e-mail) to:

Dr. rer. nat. Markus Rehm
Lecturer in Physiology and Biophysics
Department of Physiology and Medical Physics
Royal College of Surgeons in Ireland
York Street Building
Dublin 2 Ireland
email: mrehm at rcsi.ie

Key publications are available on request

posted 2008/3/15

Three research positions "Theoretical Systems Biology" in Dresden, Germany

Three research positions "Theoretical Systems Biology"
at Dresden University of Technology, Germany

Applications from highly qualified candidates are invited for
* two full postdoctoral fellow positions for up to three years and
* one PhD position for three years in theoretical systems biology, mathematical biology and computational cell biology.

The goal is to discover, in close collaboration with experimental and medical partners, novel biophysical and biochemical mechanisms of information and material transport between subcellular compartments such as the plasma membrane, Golgi and nucleus as well as the spatio-temporal regulation of such mechanisms. The new members of our group will
coordinate and conduct the above research and complement running projects which utilise a broad spectrum of theoretical tools with a focus on multi-scale modelling of spatio-temporal pattern formation.

The ideal postdoctoral candidate holds a Ph.D. in physics, applied mathematics or biology (or similar), has demonstrated expertise in systems biology, biophysics, nonlinear dynamics, stochastic methods or network analysis and has a strong interest in molecular cell biology.
The Ph.D. candidate should possess a masters or diploma degree in physics or applied mathematics. A high level of motivation and commitment are required. Strong communication skills are important for the close collaborations with experimentalists and medical doctors.

The envisaged research will be conducted at the interdisciplinary Center for Information Services and High Performance Computing (ZIH), Dresden University of Technology, Germany, which hosts a department focusing on the mathematical modelling of biological systems (head: Andreas Deutsch). The Dresden campus is characterized by a vibrant international community of researchers that performs cross-disciplinary research at
the highest level in state-of-the-art research centers. The city of Dresden and its surroundings are also rich in culture and impressive scenery. ZIH is an equal opportunity employer and strives to increase the number of women in research. We also encourage and invite applications from disabled individuals, who will be given priority if suitably qualified.

The positions are available from June 1, 2008. Deadline for applications
(by email, including contact details of two references): April 10, 2008.

Andreas Deutsch
Center for Information Services
and High Performance Computing (ZIH)
Dresden University of Technology, Germany
Tel.: +49 351 463-31943
Fax.: +49 351 463-38245
Email: andreas.deutsch at tu-dresden.de
WWW: http://theobio.mtbio.de/imc

posted 2008/3/15

Postdoctoral Fellowship: Mathematical Modeling of Viral Transcriptional Circuitry

Postdoctoral Fellowship: Mathematical Modeling of Viral Transcriptional Circuitry
U of California, San Diego

Dr. Leor S Weinberger's laboratory (recently moved from Princeton) seeks applicants for a postdoctoral fellowship (2-3 years) exploring HIV and viral transcriptional regulation from a dynamical systems approach. The specific research project is flexible and can be tailored to the interests of the individual, but should fall under the broad fields of  transcriptional
regulation and circuitry. Our lab is a joint theoretical and experimental lab ( http://chem-faculty.ucsd.edu/weinberger) that stresses close interaction between theorists and experimentalists and houses all the computational resources and the wet-lab experimental infrastructure (including several confocal microscopes for measuring single-cell transcriptional dynamics in vivo) required for joint theoretical/experimental projects. Applicants will be considered from a diverse spectrum of backgrounds  (including PhDs in mathematics, statistics, physics, biology or related areas) but preference will be for highly
motivated applicants with excellent communication skills. The ideal candidate should also have training in dynamical systems (including computer simulation skills), good interaction capability with experimentalists and a proven record of independent research. The postdoctoral fellowship provides a competitive annual stipend plus benefits and health insurance. Start date and term are negotiable. Applications are welcome from candidates of any nationality, and will be reviewed on a rolling basis. UCSD offers an outstanding intellectual environmental with many top-five ranked scientific departments (including Biochemistry and Bioengineering), a highly regarded medical school, a Center for Theoretical Biological Physics (CTBP), and close proximity to the Salk and Scripps Institutes.  Highly motivated applicants are encouraged to email a statement of research interests, CV,
and contact details for three references to lsw (at) ucsd.edu. Informal inquiries are also welcome. Please see our website for further info:http://chem-faculty.ucsd.edu/weinberger

posted 2008/2/29

Centre for Integrative Systems Biology at Imperial College (CISBIC)

Centre for Integrative Systems Biology at Imperial College (CISBIC)

A PhD position in systems biology of plants is available at Imperial College, London from 1st October 2008. The position is funded by a joint Microsoft Research/BBSRC Dorothy Hodgkin Postgraduate Award, and will be jointly supervised by Dr Radhika Desikan (Biology) and Professor Jaroslav Stark (Mathematics/CISBIC). The award, for a total
amount of £90,000 will cover tuition fees and living expenses.

The project aims to build a mathematical model of the integrated signalling networks in plant cells called stomatal guard cells. These cells regulate water and gas exchange between the plant and the environment. Modelling of the signal integration processes is essential in order to understand better how plants may be able to survive adverse conditions, such as those caused by global warming. The project will develop a dynamical model to fit the existing data. The model will in turn inform the choice of further biological experiments, and their outcome will enable more complex modelling. Deterministic methods from linear and non-linear differential equations will be employed (such as bifurcation analysis) as well as stochastic differential equations.

A student with mathematics/computer science/computational biology background (with grades equivalent to a UK first class honours degree) of a nationality from those countries eligible for the DHPA (see www.rcuk.ac.uk/hodgkin/ ) will be eligible. The student will
interact with both biologists (in RD's lab) and mathematical modellers (in JS group/CISBIC) in order to further this project.

For further details contact Dr Radhika Desikan (r.desikan at ic.ac.uk) or Professor Jarsolav Stark (j.stark at ic.ac.uk). Closing date for applications is 30th April 2008. A PDF of this advertisement can be found at http://www.ma.ic.ac.uk/~jstark/PDF/MSR%20Plant%20PhD.pdf

posted 2008/2/29

A postdoctoral position at Virginia Tech

A postdoctoral position is available immediately in John Tyson's Research Group at Virginia Tech to conduct research in the area of mammalian cell cycle regulation. The work involves modeling molecular regulatory pathways using nonlinear ordinary differential equations.
Candidates must have a Ph.D. degree, experience in mathematical modeling, working knowledge of nonlinear dynamics as well as cell physiology and molecular biology, and an interest in applying models to problems in the molecular biology of cancer. Interested applicants must apply online at www.jobs.vt.edu, posting #080127. Complete the faculty
application and attach a cover letter, resume/vita and list of 3 references. Review of applications will begin on March 9, 2008. Virginia Tech is an Equal Opportunity / Affirmative Action Institution

posted 2008/2/20

Systems Biology Posts at Aberdeen and CISBIC

We are currently recruiting to the large interdisciplinary Combinatorial Responses In Stress Pathways (CRISP) team which will be jointly based at the University of Aberdeen and at CISBIC, Imperial College London. are seeking ambitious and committed scientists to
join the CRISP team. This team will include four experimental biologists, four applied mathematicians, six PhD students supervised by the ten group leaders. The project will study the Systems Biology of stress responses in the medically important fungi Candida albicans and Candida glabrata. We will combine advanced modelling techniques
with state-of-the-art genomics, molecular biology, biochemistry and cell biology in these pathogens. This project is funded by the BBSRC under the SABR initiative for up to five years.

A PDF summary of the available posts can be found athttp://www.ma.ic.ac.uk/~jstark/PDF/SABR%20Advert%20Final.pdf

posted 2008/2/18

Environmental Protection Agency Cross-ORD Postdoctoral Program
Mapping Toxicity Pathways for Environmental Chemicals
A key mission of US EPA’s Office of Research and Development (ORD) is the development and implementation of robust and efficient methods to identify chemical hazards. Determining the mechanisms of action of toxic chemicals is a critical step toward improving our ability to achieve this mission.  A promising approach to this problem is to delineate toxicity pathways that are activated by chemicals. Toxicity pathways describe the key molecular level details of mechanisms of action and link chemical interactions at target sites with higher level adverse outcomes. The data that are required for pathway mapping come from assays that probe a system as it is perturbed by introduction of toxic chemicals. EPA researchers are generating large and diverse data sets that are ideal for use in mapping toxicity pathways. These include high throughput screening (HTS), high content screening (HCS) and genomics data from both in vitro and in vivo systems. A critical need is the development of robust analytical approaches that use these data sets to systematically map toxicity pathways.

EPA has an immediate opening at the postdoctoral level to develop new approaches to use HTS, HCS, genomics and whole animal toxicology data sets to map out toxicity pathways. This project will requires skills in bioinformatics (required to manage and manipulate large, multi-domain data sets and to link these with other related data); in statistics (required to mine the data sets for correlations that are indicative of true interactions); and in computational sciences (required to build the requisite software and databases). Novel tools will be tested on data being generated by mission critical EPA programs. The position is at the EPA campus in Research Triangle Park, NC, but will involve significant interactions with EPA researchers at other sites.

The ideal candidate would have experience in one or more of the areas of computational modeling, computer science, data mining and statistical analysis, combined with a background in bioinformatics, systems biology, molecular biology, cell biology, physiology or genomics. Because the position requires both the conceptual development and the implementation of this system, both biological knowledge and software development experience are critical.

Benefits: Salary range of $54,494 - $84,913; Full four-year appointments; Paid relocation to EPA duty location; Vacation and sick leave; Federal health benefits, life insurance, and retirement program; Travel to professional and scientific meetings; Flexible start date in 2008

Application Deadline: March 14, 2008

For more information, please contact
Richard Judson
judson.richard @ epa.gov
(919) 541-3085

posted 2008/2/13

Mathematical Modeler Job Posting
Mathematical Modeler Job Posting

Company Overview

Immunetrics is a bio-simulation company that specializes in in-silico modeling. Immunetrics modeling technology is intended to provide critical information to drug developers to accelerate and improve the drug discovery and development process by providing clinically predictive models of disease. Immunetrics' bio-simulation technology enables drug discovery and development firms to gain comprehensive insights into the potential problems facing a compound before investing significant resources into time-intensive and costly animal testing and human clinical trials. The Immunetrics models are based on dynamical systems modeling, i.e. systems of differential and algebraic equations, which represent the actual biological mechanisms that drive components of the system.

Mathematical Modeler

Primary Responsibilities:

Function as part of a team of mathematical modelers to design and develop cell-based mechanistic models of complex biological systems
Research biological literature and understand biological pathways and physiological processes
Analyze clinical data and work with statisticians to perform data analysis
Develop and test new models using Immunetrics proprietary platform
Perform fits of mathematical models to experimental/clinical data
Design and perform clinical trial simulations on Immunetrics proprietary platform
Perform routine presentations of recent research and findings
Regular meetings with physicians and investigators

PhD in Bioengineering, Chemical, Mathematics, Physics or related field
Experience with the development of mechanistic models of biological systems is required
Knowledge of biology is essential
Strong background in computation, especially differential equations and parameter estimation
Familiarity with researching biological literature using available tools
Experience with large mathematical systems is preferred, but not essential
Some knowledge of statistics is preferred, but not essential
Strong communication skills and ability to communicate with physicians and investigators.
Please submit resumes or CVs to careers @ immunetrics.com

posted 2008/2/1

Director, Division of Systems Toxicology
The U.S. Department of Health and Human Services, Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), Office of Research is seeking to hire a highly qualified scientific leader for the position of Director, Division of Systems Toxicology (DST). The successful candidate will be expected to lead the DST scientists in multi-disciplinary teams of six Centers of Excellence including Centers for Functional Genomics, Proteomics, Metabolomics, Hepatotoxicity, Toxicoinformatics and Chemistry. The successful applicant will be expected to provide research leadership, technical expertise and functional area mentorship for the inclusion of OMICs (genomic, transcriptomic, proteomic, and metabolomic), bio-imaging techniques, nanotechnology and informatic tools to support regulatory decisions including use in studies for the development of safe and effective drugs, veterinary medicines, medical devices and foods associated with the FDA's Critical Path Initiative. The fundamental idea of the Critical Path Initiative is to reduce the uncertainty about product performance throughout the product life cycle through scientific research.

The incumbent will address agency Critical Path scientific issues using a systems approach that links data from "OMICs" technologies with in vivo data to provide a comprehensive mechanistic assessment to predict and evaluate the safety of FDA regulated products.

The NCTR, located approximately 30 miles south of Little Rock, Arkansas, conducts FDA mission-related research that is of critical importance for the Agency to develop a scientifically sound basis for regulatory decisions. Over 110 Ph.D. scientists and 400 support scientists, on-site-contractors and administrative staff make up a dynamic group of professionals in the NCTR organization. Undergraduate and graduate students, post-doctoral fellows and visiting scientists also pursue education and research opportunities in a multi-disciplinary team atmosphere. For more information on NCTR research and training activities, visit http://www.fda.gov/NCTR.

In the Division Director-level position, the incumbent will be expected to be a visionary leader and to establish a nationally recognized research program in systems toxicology to support the Agency's mission. The appointee will represent, manage and provide leadership to DST multi-disciplinary teams of toxicologists, biologists, chemists, molecular biologists and toxicoinformatics scientists.

The Division Director will perform the full range of administrative duties required to manage and supervise a diverse staff of professional research scientists and technical support staff with expertise in areas including, but not limited to, biology, chemistry, molecular biology, toxicoinformatics, and computational chemistry. The incumbent is responsible for recruiting new senior, support, and postdoctoral staff to maintain a state-of the art systems toxicology research program. The Director will participate in the development of intermediate and long-range research plans and goals, evaluates specific research proposals, conducts employee appraisals, and identify budget and facility needs and critiques manuscripts and abstracts. The incumbent will be responsible for furthering the goals of equal employment opportunity by adhering to nondiscriminatory employee practices.

The position requires a Ph.D., M.D. or equivalent with demonstrated success in leading a multi-disciplinary team, a strong publication record in peer reviewed journals, relevant administrative experience, and a strong independent research program. Preference will be given to individuals with a demonstrated record of accomplishments in proteomics, metabolomics, functional genomics, or toxicoinformatics. Evidence of effective planning, organization and decision-making capabilities and excellent interpersonal and communication skills is required.

This is an excepted civil service position under Title 42 USC 209(f) with the salary negotiable and commensurate with experience and qualifications (range of $130,000 - $190,000). The candidate must be a U.S. citizen or permanent resident. Benefits include health and life insurance options, retirement, paid holidays, vacation and sick leave. Relocation expenses may or may not be paid in accordance with FDA policy.
Interested individuals should send a letter of application with a curriculum vitae, statement of proposed and current research plans, copies of up to five peer reviewed publications, and names with complete contact information of three references to the attention of Mary Ann Hutchison, Office of Management Services, NCTR, 3900 NCTR Road, Jefferson, AR 72079.

Applications must be postmarked no later than February 15, 2008. FDA is an Equal Opportunity Employer. FDA/NCTR is a smoke free environment.

posted 2008/1/25

Computational Systems Biology Postdoctoral Fellowship at Boston University
Computational Systems Biology Postdoctoral Fellowship at Boston University

Available immediately to develop and apply computational techniques to reverse engineer and analyze gene regulatory networks in bacteria and mammalian cells. Expertise in computational techniques and algorithm development in required. Applicants must have a PhD in physics, engineering, bioinformatics or a related discipline. Applicants should send a brief statement of research interests, a CV and names of three references to: Dr. J.J. Collins, Department of Biomedical Engineering, Boston University, 44 Cummington St., Boston, MA, 02215, jcollins @ bu.edu

posted 2008/1/15

Post-doctoral Openings in Systems Biology (starting in 2008)
Post-doctoral Openings in Systems Biology (starting in 2008)

We are advancing new technologies to better understand the growth, spread and evolution of viruses. Active and new NIH-supported projects are in three areas: (1) flow-enhanced spread and characterization of infections in microfluidic devices, (2) phenotype distributions from measurements and models of infections initiated by single virus particles, (3) dynamics of virus populations in anti-viral environments. Systems of current interest are influenza virus and vesicular stomatitis virus. The most competitive applicants will be exceptionally creative, highly-motivated individuals with significant experience in:

Engineering or physical sciences: modeling or simulation of reactive systems, fluid and particle dynamics, and/or microfluidics
Quantitative biology: live-cell reporting of gene expression, RNA and protein quantification, microscopy, imaging and analysis, and/or flow cytometry

Madison, Wisconsin is an attractive and affordable city surrounded by beautiful lakes. It routinely ranks as a 'best place to live,' and residents thrive on its rich diversity of outdoor and cultural opportunities. All researchers in our laboratory develop and maintain
standards of institutionally-approved biosafety (BSL 2) protocols.

Forward your CV with cover letter, and have three letters of reference sent to John Yin by e-mail (yin @ engr.wisc.edu), fax (608/262-5434) or regular mail: Department of Chemical and Biological Engineering, University of Wisconsin, Madison, WI 53706-1607 USA.

posted 2008/1/9

QB3 Fellow for Systems Biology, University of California, San Francisco
QB3 Fellow for Systems Biology
University of California, San Francisco

The California Institute for Quantitative Biosciences (QB3) at the University of California San Francisco (UCSF) invites applications for Fellow positions in Systems Biology. UCSF seeks exceptional individuals to carry out an independent and creative research program in quantitative approaches to understand complex biological systems.
The focus of the positions is primarily on computational and theoretical models, however, Fellows will have the opportunity to work in wet labs through collaboration. UCSF
provides an interdisciplinary and highly interactive collegial environment.

Appointments are for three years, with generous salary and research support. For more information about our programs visit: http://ipqb.ucsf.edu and http://www.qb3.org.

Candidates must have strong quantitative backgrounds and have received, or are soon expecting, a Ph.D. degree in relevant areas, including Biology, Mathematics, Physics,
Chemistry, Computer Science, or Engineering.

Applications should be submitted by January 31, 2008 to receive full consideration. We will continue to review applications until the positions are filled. Please send CV,
summary of current/past research (1-2 pages), description of future research (1-2 pages), and 2-4 letters of recommendation to:

Kalai Diamond
Attn: QB3 Fellow Search Committee
University of California, San Francisco
1700 4th Street, Campus Box 2542
San Francisco, CA 94143-2542
Kalai.Diamond @ ucsf.edu
Fax: (415) 514-2073

UCSF is an affirmative action/equal opportunity employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for covered veterans.

posted 2007/12/13

ASSISTANT PROFESSOR: Systems Biology of Woody Plants, NC State University.
ASSISTANT PROFESSOR: Systems Biology of Woody Plants, NC State University.

Position Description:
The Department of Forestry and Environmental Resources at North Carolina State University invites applications for a 12-month, tenure-track position. Responsibilities will be approximately 50% teaching and 50% research. Duties will include teaching at the graduate and undergraduate levels; advising undergraduate and graduate students; and developing a strong, externally funded research program in systems biology of woody plants, preferably on topics related to biomass production and processing. Demonstrated potential for productive collaboration with faculty within the Department and other scientists is strongly desired. Salary and benefits will be nationally competitive and commensurate with qualifications.

* PhD degree or equivalent in a biological science or related field
* Expertise in one or more of the following areas: genomics, bioinformatics, biotechnology, genetics, forestry, or ecology; and interest in working at the systems level in collaboration with faculty in one or more of the other areas
* Ability to attract external funding.
* Excellent oral and written communication skills

About the Department:
The Department of Forestry and Environmental Resources (www.cnr.ncsu.edu/for/) has 58 faculty with a wide variety of strengths in forestry and natural resources management, policy, and economics, environmental technology, fisheries and wildlife, tree improvement, silviculture, forest biotechnology, international forestry, biodiversity, conservation and restoration ecology, and geographic information systems. The Department offers undergraduate, masters and doctoral degrees, and currently has 346 undergraduate and 117 graduate students. Consistent with the land grant mission of NCSU, the Department has a strong commitment to developing partnerships with stakeholders. Faculty, staff, and students work together with business, industry, government, community groups, and non-government organizations to address a wide range of challenges facing our state and the world. These partnerships facilitate research and discovery, teaching and learning, and outreach and service. Active research programs within the Department generate about $6 million annually in extramural funds.

About NC State University:
North Carolina State University (http://www.ncsu.edu) is one of the nation's leading public land-grant universities with a total enrollment of approximately 31,000 students. The university is located in the capital city of Raleigh (http://www.webs4you.com/raleigh/) and (http://triangle.citysearch.com/), and is primarily housed on about 2,110 acres within the city.

Application Process:
Applicants should submit a letter of application, curriculum vitae, copies of college transcripts, and contact information for at least three references to:

Dr. Ross Whetten, Chair: Systems Biology Search
Department of Forestry and Environmental Resources
Box 8008
North Carolina State University
Raleigh, NC 27695-8008

For questions about this position or the department, contact Ross Whetten < ross_whetten @ ncsu.edu> (919-515-7578) or Barry Goldfarb, Department Head (919-515-4471). Review of applications will begin on January 11, 2008 and will continue until the position is filled. The position is available July 1, 2008.

NCSU is an EO/AA employer. In addition, NC State University welcomes all persons without regard to sexual orientation. For ADA accommodations contact Eileen Broderick, . Phone: (919) 515-2893, fax: (919) 515-6193. Proper documentation of identity, academic credentials and employability in the United States will be required.

posted 2007/12/12

PhD Positions: Mathematical Modelling and Analysis of Cell Death
Applications are invited for two PhD positions in the Systems Biology Group of the Hamilton Institute at the National University of Ireland, Maynooth. The vacancies are in the area of mathematical modeling and analysis of cell death.

The advertised positions are part of a Higher Education Authority investment for a National Biophotonics Imaging Platform (NBIP) for Ireland. NBIP is the largest European network in Biological Imaging and its mission is to provide an integrated national infrastructure in research, education, technology development and industry collaboration for Biophotonics and Imaging.

The Systems Biology Group at the Hamilton Institute in collaboration with the Department of Physiology and Medical Physics at the Royal College of Surgeons in Ireland, will develop new algorithmic methods that perform the transition from temporal/spatial images to a quantitative mathematical representation of the corresponding dynamical variations (as part of the Image to Mathematical Model Transition (IMMT) facility of the NBIP).

In particular, the advertised vacancies will be focussed on (but not limited to) the following application areas:

(1) Systems analysis of effector caspase activation models.

Candidates interested in the above application area should hold a degree in Engineering/Applied Mathematics or a related field. Some background in biology or biochemistry is highly desirable.

(2) Mathematical modelling of the mechanisms of cell death.

Candidates interested in the above application area should hold a degree in Biochemistry/Biophysics/Bioinformatics/Engineering or a related field.

In both cases, applicants should have a sound scientific record in the area of mathematical modelling and model analysis. Good communication, interpersonal and presentation skills are required, as is proficiency in both written and spoken English.

The positions are available for a four-year period.

For further information on the Hamilton Institute and the Systems Biology Group, please refer to: www.hamilton.ie and www.systemsbiology.ie. Additional information about the posts can be obtained from Dimitris Kalamatianos (dimitris.kalamatianos @ nuim.ie).

To apply, candidates should submit a detailed CV, including a list of publications (if available), motivation letter, scientific interests, as well as the names and addresses of two referees for letters of recommendation to: hamilton @ nuim.ie. The start date of the projects is January 2008 but can be negotiable.

posted 2007/12/04


Applications are invited for post doctoral fellowship available at the JM Rendel laboratories in the Division of Livestock Industries, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Rockhampton, Australia. This position relate to high profile strategic scientific research projects in the area of Systems Biology and Quantitative Genomics in Livestock and are funded by the Office of the Chief Executive (OCE) of CSIRO.

Project: Systems Biology - Genetic dissection of -omics variations
Reference No. 2007/960

This is a three year appointment within the Systems Biology & Quantitative Genomics Group (Dr Haja Kadarmideen) at the JM Rendel laboratories, CSIRO Livestock Industries in Rockhampton, Queensland, Australia. The fellow will work closely with Computational Biology Group (Dr Toni Reverter) and Bioinformatics group (Dr Brian Dalrymple) at Queensland Bioscience Precinct (QBP) in Brisbane, Statistical Genetics Group (Assoc. Prof. Peter Thompson) at the University of Sydney, Camden and with Systems Biology group (Dr Markus Herrgard) at the University of California San Diego, USA.

Full description of the position and project, selection criteria and application package for this position can be found at the following web link: http://recruitment.csiro.au/asp/Job_Details.asp?RefNo=2007%2F960

This position is open to international applicants and offers an excellent opportunity for recent PhD graduates / young scientists to work in a rapidly emerging field of systems genetics and systems biology with internationally reputed group(s). In addition to computational / insilico investigations, training with large high throughput genomic and transcriptomic databases from beef cattle and sheep experiments are available. CSIRO offers a generous annual salary in the range of AUS 65000 to AUS 72000 plus employer's contribution to superannuation. Application must be lodged online using the above web link.

Deadline for lodging application online is 5 NOVEMBER 2007.

Primary contact for informal enquiries:
Dr Haja Kadarmideen
Principal Research Scientist and Group Leader,
Computational and Systems Biology Stream,
CSIRO Livestock Industries, JM Rendel Laboratory, Ibis Ave
Rockhampton QLD 4701 AUSTRALIA

Phone: + 61 7 4923 8266 ; Fax: + 61 7 4923 8222 ;
Email: Haja.Kadarmideen @ csiro.au
Web: www.csiro.au/li

posted 2007/10/31

Systems Biologist, Tenure-Track
California State University, Fresno, is searching for a tenure track Assistant Professor in Systems/Computational Biology. The successful candidate is expected to develop a research program in a current area of systems biology, including quantitative manipulation of genomic, proteomic and/or metabolomic datasets from complex physiological networks to investigate basic questions at any level of biological organization from molecular to tissue level to whole organism. Additionally, the successful candidate will be expected to teach an upper division majors/service course on a rotational basis, and an undergraduate and a graduate course in their areas of expertise (e.g. Bioinformatics). An earned doctorate (Ph.D.) in Biology or related field is required. Strong preference will be given to candidates with post-doctoral experience. Send completed application, including form available at www.csufresno.edu/aps/vacancy/sc1.pdf, a cover letter, curriculum vitae, statements of teaching and research philosophy, and three current letters of reference (dated within the last 12 months) to: Dr. Jason Bush, Committee Chair, Department of Biology, California State University, Fresno, 2555 E. San Ramon Avenue M/S SB73, Fresno, CA 93740-8034, or to jbush @ csufresno.edu, Phone: (559) 278-2068, Fax: (559) 278-3963. For full consideration, all materials must be received by 14 January 2008. California State University, Fresno is an Equal Opportunity Employer.

posted 2007/10/26

Postdoctoral Position in Systems Biology
Postdoctoral Position in Systems Biology

Systems Biology of Apoptotic Cell Death Signaling Networks

Applications are invited for a Postdoctoral position in Systems Biology (initially for two years) in the Department of Physiology and Medical Physics/RCSI, Dublin, Ireland. The position is funded by the Health Research Board Ireland (HRB).

Candidates should have a background in systems biology, computational biology, biophysics or applied mathematics, and be experienced in numerical analysis/programming (e.g. C++, MATLAB, Mathematica). Excellent written and communication skills and a high level of motivation and commitment are required. The institute is located in the heart of Dublin city and offers an international and interdisciplinary working environment spanning the fields of systems biology, cancer and molecular biology, biophysics, and mathematics.

Apoptotic cell death is regulated by complex signalling networks spanning several compartments within living cells. Impaired apoptosis can result in developmental disorders and cancer. In an industry collaboration with SIEMENS (Medical Division) the applicant will translate biological systems into novel computational models that allow the spatiotemporal and quantitative prediction of signalling events, and the identification of key regulatory factors or threshold mechanisms deciding on apoptotic cell death.
The applicant will work interactively with the experimentalists to discuss model validity and restrictions. Generated models will qualitatively and quantitatively be validated by experimentalists measuring the real time kinetics of key signalling events within living cells.

Applications should include CV and names and addresses of two referees and be sent (preferably by e-mail) until 30.11.2007 to:

Dr. rer. nat. Markus Rehm
Lecturer in Physiology and Biophysics
Department of Physiology and Medical Physics
Royal College of Surgeons in Ireland
York Street Building
Dublin 2

email: mrehm @ rcsi.ie

Key publications are available on request

posted 2007/10/03

Research assistant or postdoc researchers on computational systems biology projects in the Alzheimer's disease
The Medical Image Computing Lab of the Methodist Hospital Research Institute and the Department of Radiology, the Methodist Hospital, and the Weill Medical College of Cornell University is looking for research assistant or postdoc researchers to work on computational systems biology projects in the Alzheimer's disease. The qualified candidates should have strong experience with network modeling, bioinformatics, and/or systems biology. Our lab and department has fast growing potential. We provide competitive package of compensation.
For more information, please contact Mr. Tianming Liu at tliu @ tmhs.org or tliu @ bwh.harvard.edu

posted 2007/09/21

Faculty Position in Plant Biology
Michigan State University
East Lansing, MI 48824

 Faculty Position in Plant Biology

The MSU-DOE Plant Research Laboratory (PRL) has a twelve-month tenure-track faculty position available at the Assistant Professor level. We seek to identify individuals who investigate fundamental questions in plant biology that fall in the continuum between photon capture and the deposition of energy-rich molecules, or plant-environment interactions that influence these processes.

The PRL, with core funding from the U.S. Department of Energy, provides an excellent environment for creative research in plant biology. Michigan State University has a history of exceptional breadth and depth in the plant sciences and provides a simulating atmosphere with excellent colleagues and facilities. PRL faculty members are jointly appointed in an appropriate academic department.

Applicants should have postdoctoral research experience with demonstrated productivity and evidence of potential for independent research. To assure consideration, applications should be submitted electronically to prlsrch @ msu.edu by October 1, 2007. Applications should include curriculum vitae, a summary of research accomplishments, and a brief description of future plans. Candidates should also arrange to have three letters of reference submitted. Questions regarding this position should be directed to prlsrch @ msu.edu.
Michigan State University is an affirmative action, equal opportunity employer.

MSU is committed to achieving excellence through cultural diversity. The university actively encourages applications and/or nominations of women, persons of color, veterans, and persons with disabilities.

posted 2007/8/27

Head of a Research Group for Systems Biology
Interdisciplinary Center for Clinical Research Muenster, Germany in the Medical Faculty of the Westfaelische Wilhelms University of Muenster

Head of a Research Group for Systems Biology

The Interdisciplinary Center for Clinical Research (IZKF) in the Medical Faculty of Muenster focuses on disease oriented research predominantly in the fields of inflammatory, infectious, cardiovascular and neurological diseases. The Center also takes great efforts to make state of the art technologies available to its scientists. Central to this is the technology platform on Integrated Functional Genomics, offering services in the area of Genomics, Proteomics and Bioinformatics. Due to increasing technical sophistication and the rapid development towards single cell analysis, the latter increasingly requires more complex data analyses, e.g. pattern recognition, pathway identification etc.

The IZKF is offering the position of Head of a Research Group for Systems Biology with special emphasis on inflammation and infection. Appointment will be according to the German salary scale (E14) for a period of five years. The successful candidate can recruit one post-doctoral fellow (E13) or two doctoral students (E13, 50%), will be provided with 25.000 Euros/year for consumables, and will have access to research core proteomics, genomics and bioinformatics facilities. Opportunities exist for active collaboration with faculty members studying related themes.

The IZKF is seeking an exceptional, ambitious individual to fill this position. Candidates should have a MD and/or PhD degree, with a strong record of peer-reviewed publications, extramural funding and an active research program. Applicants should demonstrate their potential to develop an outstanding research program with a team of young scientists whose research interests are in accord with the Center's research activities, and should posses the ability to work collaboratively with other faculty members.

To apply please submit a letter of application, including a statement of current and future research interests, curriculum vitae, sample publications, and the names of three referees to the following address by September 07, 2007.

IZKF Muenster
Scientific Office
Westfaelische Wilhelms University Muenster
Domagkstrasse 3
D-48149 Muenster

For further information please visit our website at www.izkf.uni-muenster.de or contact us at izkf.muenster at uni-muenster.de; Tel: +49(0)251-8358695

The IZKF Münster is an equal opportunity employer and strives to increase the number of women involved in research and teaching. We also encourage and invite applications from disabled individuals, who will be given priority if suitably qualified.

posted 2007/8/15

Senior Scientific Researcher-Computational/Systems Biology Software Programmer
Senior Scientific Researcher-Computational/Systems Biology Software Programmer

Position Description
Seralogix is seeking Scientific Software Programmers to support research and development of new systems biology software for genomic/proteomic modeling and analysis of diseases of high public health concern. The successful applicant will provide scientific research and computational support for ongoing and future research and development for bioinformatics, genomic, proteomic and systems biology projects.

Candidates must have a strong background in software development, mathematics and statistics. Experience in bioinformatics, systems biology, data mining or pattern recognition is a plus. The candidate should be able to demonstrate the ability to quickly learn and apply methods and procedures to accomplish research and development objectives. The ideal candidate must have demonstrated ability to:
- Develop scientific-based software independently and in a team environment.
- Design and implement statistical and probability algorithms
- Communicate the algorithms and/or results to both technical and non-technical audiences.
- Methods of advance machine learning, Bayesian and Neural Net

The candidate should be fluent in Java, SQL and Perl, PHP or similar programming language, C++, MATLAB a plus. Proven ability to design and implement computational algorithms, user interfaces, APIs. Installing, configuring, and maintaining RDBMSs and developing software using RDBMS APIs.

Minimum Bachelor's Degree in Computer Science, Mathematics or related scientific discipline. This position requires strong analytic, organizational, written, and verbal communications skills. The candidate must be an innovator and self-starter, and work equally well in interdisciplinary teams or independently.

To Apply
Please email your resumes/CV to careers @ seralogix.com.

About Seralogix
Located in Austin, TX, Seralogix is a privately owned bioinformatics and research services company with a mission to serve the unmet genomic/proteomic based computational analysis and modeling needs for human and animal diseases of high public health concern. Seralogix is developing new computational systems biology methods and tools to support genomic/proteomic investigations. Our clients include the National Institutes of Health, academic institutes, and pharmaceutical companies.

posted 2007/7/27

Research Fellow in Systems Biology - Analysis of Biochemical Networks
Research Fellow in Systems Biology - Analysis of Biochemical Networks using Robust Control Theory

The Research Fellow will join the University of Leicester Systems Biology Lab (www.SBLab.org), based in the internationally leading Control and Instrumentation Research Group, to work on this BBSRC funded project.
The research is focussed on the development and application of techniques for analysing biomolecular network models, with particular application to models of cyclic-AMP oscillations in aggregating Dictyostelium cells, and the genetic circuits underlying control of tryptophan production in E.coli. As well as developing novel analytical techniques in collaboration with Dr. Declan Bates and Prof. Ian Postlethwaite, the Research Fellow will have the opportunity to test these methods via interaction with experimentalists in the laboratory of Prof. Pat Heslop-Harrison at Leicester (www.molcyt.com). This is an exciting opportunity for a young researcher to join a genuinely multidisciplinary team of researchers working at the Life Sciences Interface. Applications are welcome from candidates holding (or about to complete) a PhD in Control or Systems Engineering, Physics or Mathematics.

Salary: £27,465 to £31,840 pa, available from October 2007 for 24 months. Downloadable application forms and further particulars are available from www.le.ac.uk/personnel/jobs or from Personnel Services, tel: 0116 252 2758, fax: 0116 252 5140, email: recruitment3 @ le.ac.uk .
Please note that CVs will only be accepted in support of a fully completed application form. Closing date: 30th September 2007. Informal enquiries are welcome to Dr. Declan Bates (dgb3 @ le.ac.uk).

posted 2007/7/19

Post-doc in Systems Biology of Cancer
A two years post-doctoral position is open at the Institute of Mathematical Research in Rennes (France) for Computational Systems Biology of Cancer, starting with September 1, 2007.

This position is created to support the participation of IRMAR to the interdisciplinary project SITCON (Modeling signal transduction induced by a chimeric oncogene) in collaboration with the Curie Institute in Paris and with IRISA in Rennes (Symbiose team).

Job description:
Qualitative modeling of molecular pathways involved in the Ewing inducible cellular model.

The role of this post-doc is to apply and to extend existant qualitative approaches to heterogeneous data in cancer. These approaches use qualitative equations, graph theoretical methods and polynomial coding in Galois fields. Qualitative modeling will be used for three purposes:

1) Construction and correction of graphical models which integrate information from heterogeneous data: micro-arrays, micro-RNA, ChIP-on-chip, CGH, time series. Data is provided by our collaborators in Curie Institute.

2) Qualitative analysis of transduction pathways and of their cross-talk.

3) Experiment design.

The successful candidate will collaborate with Ovidiu Radulescu in IRMAR and with several members of the group Symbiose (computer science, IRISA).

Requirements for candidates:
We expect the candidate to have formation in mathematics, physics or computer science. Experience in modeling molecular mechanisms in biology will be appreciated. It will be advantageous to be able to demonstrate some knowledge of basic biological mechanisms involved in cancer (regulation of cell cycle, apoptosis, etc.) and to have experience of collaboration with biologists for solving concrete biological problems. Another advantage will be familiarity with standards in Systems Biology (SBML, BioPax) and with existing software for pathway modeling. Programming skills are needed. Good communication skills are required.

Job location:
Institute for Mathematical Research and IRISA, Campus de Bealieu, 35042 Rennes. This job offers true interdisciplinar environement. IRMAR is one of the best university institutes in France, as well as a world-class mathematical center. IRISA, a flexible and excellently managed structure, strongly supports interdisciplinarity: many IRISA teams host mathematicians, biologists and physicists working on interdisciplinar projects. Rennes is a small, enjoyable university town, in the pleasant to live Brittany (north-west of France), not far from unique sea shore.

Contact for more information:
ovidiu.radulescu at univ-rennes1.fr

For more information about IRMAR:
For more information about IRISA:

Applicants should submit a letter of motivation (with reference ANR SITCON), a detailed CV with publication list, and the names of three referees by e-mail to ovidiu.radulescu at univ-rennes1.fr

posted 2007/6/5

Call for Team Leaders CNRS ATIP Programmes
(Actions Thematiques et Incitatives sur Programme)
Call for Team leaders 2007-2008

The "Departement des Sciences du Vivant" (Life Sciences Division) of the CNRS, offers an opportunity to scientists at the end of their postdoctoral training for developing an innovative independent research project while setting up their own group within a CNRS laboratory. Successful applicants will receive a three year grant (150 kEuro for equipment and consumables), the possibility of hiring a postdoctoral fellow for two years, at least 50 m2 of lab space and, whenever possible, technical assistance. At the end of the three years, the ATIP team leaders may compete for a two year extension through the "ATIP Plus" programme.

Eight programmes concern specific research areas (Biodiversity and ecosystem dynamics, Cell biology and Immunology, Developmental biology, Genetics, Microbiology, Systems biology, Neurobiology: from molecular to cognitive neurosciences, Structure-function relationships, Dynamics of biomolecules and their assemblies), and one (ATIP "Blanche") is open to any project of high scientific quality related to Life Sciences. Applications from scientists presently working in a foreign country are particularly encouraged.

Applicants must be less than 40 years old, or have defended their PhD thesis within the last ten years (exception may be made for women with children). At the beginning of the ATIP contract, applicants need not hold a permanent position within a French research organisation such as CNRS, INSERM or University. In this case, the CNRS will hire the team leader, and salaries will range between 3,400 and 3,800 Euro per month. However, he/she must apply for and obtain such a tenured position in order to be eligible for a possible two year extension ("ATIP Plus" programme). Applications for tenured positions are independent from the ATIP programme and have to be submitted in parallel. Applicants are not allowed to join a laboratory in which they have been PhD student or postdoctoral fellow for years.

Application forms and more detailed information are available either directly or through the web site of the CNRS: http://www.cnrs.fr/infoslabos/atip/lifeatip.htm. Applications must be written in English and addressed before October 1st, 2007 to:
Jean HOUMARD - Charge de Mission
CNRS - Departement des Sciences de la Vie
3, rue Michel Ange - F-75794 Paris Cedex 16.
E-mail: sdv-atipe at cnrs-dir.fr

posted 2007/6/5

Vacant Positions in Systems Biology at AstraZeneca
As one of the world's leading pharmaceutical companies, we recognise the huge potential Systems Biology offers drug development. That's why we want to enhance our capability in this area. Join us in any of these opportunities, and you'll be part of a team making a real contribution to the development of innovative, effective medicines.

  • Team Leader - Computational Biology
  • Senior Scientist - Computational Biology
  • Scientist - Computational Biology - Modelling
  • Associate Principal Scientist - Bioinformatics
  • Scientist - Bioinformatics

    For details, please check PDF. or Search under the appropriate reference at careers.astrazeneca.co.uk.

    posted 2007/5/11

  • postdoctoral position in computational system biology
    One postdoctoral position in computational system biology is available in the research group of Ao Ma in the Department of Physiology and Biophysics at the Albert Einstein College of Medicine. The research subject is stochastic modeling of the regulatory network of spindle dynamics during cell mitosis. The project involves close interaction with experimental groups, and will provide a unique and exciting research experience.

    Applicants should have a PhD in a relevant field, a strong background in system biology or computational physics/chemistry and excellent programming skills. The starting date is negotiable, and applications will be received until the position is filled. The initial appointment is for one year with reappointment for a second or a third year upon mutual agreement.

    Applications (including a CV, a publicatoin list, and contact information of three references) should be sent to Dr. Ao Ma through email (ama @ aecom.yu.edu).

    posted 2007/5/10

    Postdoctoral positions in Computational Systems Biology
    The Computational Biology and Biological Physics group at Lund University (http://cbbp.thep.lu.se/) is recruiting several postdoctoral fellows (2 + 1 years) in the areas of dynamical modeling transcriptional networks, intercellular signaling and cell growth in plants and processes related to stem cell and cancer biology. In addition to dynamical modeling, bioinformatic efforts will also be involved. Prior experience in the field is desirable. However, in cases of extreme talents, we invite researchers with other backgrounds also to apply.

    The group, which is generously funded by prestigious grants from the Human Frontier Science Program and the Swedish Foundation for Strategic Research, is truely cross-disciplinary and interacts seamlessly with and is part of:
    - The Lund Strategic Research Centers for Stem Cell Biology and Cell Therapy
    - Create Health - the Lund Strategic Center for Clinical Cancer Research
    - The Computable Plant Project at Caltech and UCI.

    Lund University is the largest campus in Scandinavia and is conveniently located within an hour from Copenhagen and its airport (http://cbbp.thep.lu.se/contact/).

    Successful candidates should hold a PhD in Computational Biology /Physics /Applied Mathematics /Bioinformatics /Computer Science or Engineering.

    Appointments will be made as successful candidates are identified.

    Candidates who are willing to work in an exciting environment on the cutting edge of systems biology, genomics, proteomics and translational medicine are encouraged to apply. Please send a CV, a brief description of previous research and the names of three references to:

    Professor Carsten Peterson
    Computational Biology and Biological Physics
    Department of Theoretical Physics
    Lund University
    S?vegatan 14A
    SE-223 62 Lund, Sweden
    Email: carsten @ thep.lu.se


    Assistant Professor Henrik J?sson
    Computational Biology and Biological Physics
    Department of Theoretical Physics
    Lund University
    S?vegatan 14A
    SE-223 62 Lund, Sweden
    Email: henrik @ thep.lu.se

    posted 2007/5/3

    Postdoc in systems biology
    The postdoc will implement a computational model of transcriptional networks that is both realistic enough to be related to yeast data and simple enough for experimental evolution to be rapidly simulated. The model will then be used to study a range of questions, including network topology and the evolution of robustness/canalization to mutation, to the environment, and to the stochasticity associated with small numbers of molecules in cells.

    The postdoc will work closely with PI Joanna Masel
    (http://eebweb.arizona.edu/Faculty/bios/masel.html) at the University of Arizona in Tucson, and will also interact with collaborator Mark Siegal (www.nyu.edu/fas/dept/biology/faculty/siegal) at NYU.
    The position is renewable over multiple years, and is available immediately. Ph.D. with modeling and/or scientific programming experience is required. Experience in systems biology, genomics, evolutionary biology and/or the biology of transcription factors and their binding sites is preferred.

    Contact Joanna Masel at masel at u.arizona.edu for more information and to apply.

    posted 2007/4/11

    Researcher / Postdoctoral positions for Systems Biology available
    ERATO-SORST Kitano Symbiotic Systems Project (http://www.symbio.jst.go.jp/) has an opening for researcher or post-doctorial fellow to work on systems
    biology research. The project is funded by Japan Science and Technology Agency as a part of SORST Program and carried out by The Systems Biology Institute.

    A position is available for those who are interested in development of the computational platform for systems biology; including development of CellDesigner, SBML, and SBGN, application of web 2.0 to biological knowledge accumulation, and other novel ideas on computational platform for systems biology.

    Extensive collaborations with other institutions in Japan and around the world are expected.
    The position is based on annual contract and for approximately two years until the end of the current funded project. The office and laboratory is in Tokyo . Salary range and benefits is based on JST scale.

    For details, please contact Hiroaki Kitano (job at sbi.jp) with your research interest, major papers, and CV. Title of e-mail should be "SORST POSITION: your name"

    posted 2007/2/6

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