Systems-Biology

POSTDOCTORAL POSITIONS IN THEORETICAL BIOPHYSICS

Mon, 30 Jan 2012 11:03:01 +0900

Department of Health and Human Services
National Institutes of Health
National Heart, Lung and Blood Institute

Postdoctoral positions are immediately available in the Theoretical Cellular Physics Section of Biochemistry and Biophysics Center at the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD. Applicants should have PhD in theoretical chemistry, physics, applied math or engineering. Candidates with theoretical modeling experiences in biophysics and strong computational skill are highly desirable. Projects would utilize sophisticated statistical mechanics techniques to investigate mechanochemical couplings in various cellular processes, including membrane mechanics, cytoskeleton dynamics and reaction networks. All the projects would be in extensive and close collaborations with experiments. For more information, see: http://www.lobos.nih.gov/tcps/index.shtml

Appointment and salary are dependent on experience. Applicants should submit, in a PDF file, a letter of interest, curriculum vitae, and three letters of reference to: Dr. Jian Liu at jian.liu @ nih.gov

HHS and NIH are Equal Opportunity Employers. Applications from women, minorities and persons with disabilities are strongly encouraged.

Workshop: Systems Biology of Tumor Metronomics

Fri, 27 Jan 2012 11:19:10 +0900

Tufts University Boston, MA, USA
http://www.cancer-systems-biology.org/workshop.html

Doctoral Candidate in Systems Biochemistry

Thu, 19 Jan 2012 13:47:34 +0900

The University of Luxembourg is looking for the newly established Luxembourg Centre for Systems Biomedicine (LCSB) for a Doctoral Candidate (PhD student) in Systems Biochemistry Ref.I1C-DIR-COM-11ICOO Fixed-term contract 3 years, 40h/week renewable once Student and Employee status The PhD student will be a member of the highly interdisciplinary research centre, integrating experimental biological and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalised medicine. Area: Biochemistry/Medical Biochemistry/Neurochemistry. Mission: Experimental determination of metabolic flux and concentration is a critical tool for developing understanding of the physiological state of a cell. Using isotopically labeled substrates with different labeling patterns, experimental techniques are used to measure the mass isotopomer distributions of select metabolites. Estimation of metabolic flux is by integration of mass isotopomer distributions with an isotopomer (isotope isomer) mapping model, that traces the path of each isotopomer through a metabolic network. Recently an algorithm for automated generation of draft genome-scale isotopomer mapping models has been developed. The latest reconstruction of human metabolism (Recon 2.0) is a stoichiometric model of a generic human cell. It is necessary to tailor Recon 2.0 to represent the metabolic capabilities of a particular cell type of interest. Extensive manual curation of neurochemical experimental data is necessary to tailor Recon 2.0 to accurately represent the metabolism of a normal neuron. A tailored stoichiometric model of a dopaminergic neuron, that also represents atom transitions for each reaction, would be an invaluable resource for estimation of metabolic flux and concentration in cultured dopaminergic cell lines. Tasks: To address the aforementioned challenges, the PhD project objectives are: Reconstruction of a tailored stoichiometric model of a normal dopaminergic neuron by literature review. Manual curation of an existing algorithmically created draft isotopomer mapping model of Recon 2.0 to retain only biochemically realistic atom transitions. Biological interpretation of whole cell metabolic flux and concentration data in normal and diseased dopaminergic neuronal cells toward a deeper understanding of Parkinsonism pathogenesis. Profile: A broad and deep knowledge of metabolic biochemistry e.g. M.Sc. level Medical Biochemist, Biochemist, Neurochemist. Excellent English writing and speaking skills. Offer: Contribution to an international, interdisciplinary project: Dr. Karsten Hiller, LCSB, Dr. Ronan Fleming, Center for Systems Biology, University of Iceland (CSBUI).International interdisciplinary training: In the first year, a 6 month training period in metabolic network reconstruction & modeling at the CSBUI. The University of Luxembourg offers competitive salaries and is an equal opportunity employer. Application: All applications (in English) should contain the following documents: A detailed curriculum vitaeCover letter mentioning the reference number. List of publications. Description of past research experience and future interests. Name and addresses of three referees Please send your electronic applications until the Feb 3rd 2012 to the following address: katrin.effenberger@uni.lu

HSB 2012 - First International Workshop on Hybrid Systems and Biology

Thu, 19 Jan 2012 13:32:09 +0900

Newcasle upon Tyne, UK,
Colocated with CONCUR 2012

http://hsb2012.units.it/

CMSB 2012 10th International Conference on Computational Methods in Systems Biology

Tue, 10 Jan 2012 11:19:01 +0900

Royal Society, London, UK

http://www.brunel.ac.uk/cmsb2012

Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB-2012)

Mon, 09 Jan 2012 11:51:18 +0900

Novosibirsk, Russia
http://conf.nsc.ru/BGRSSB2012

FOSBE (Foundations of Systems Biology in Engineering) 2012

Mon, 09 Jan 2012 10:00:00 +0900

Tsuruoka, Japan
http://fosbe2012.org/

Postdoctoral Research Fellow in Computationa Systems Biology

Thu, 05 Jan 2012 15:28:23 +0900

Application End: Saturday March 31 2012

The Laboratory of Computational Systems Biology at the Faculty of Informatics, Masaryk University is currently expanding its research team and is looking for highly motivated and talented individuals to a three year-fixed term post.

The position is available to participate in a project focused on parameter estimation in computational systems biology.

A central challenge in computational modeling of biological systems is the determination of the model parameters. Typically, only a fraction of the parameters (such as kinetic rate constants) are experimentally measured, while the rest are often fitted. The fitting process is usually based on experimental time course measurements of observables, which are used to assign parameter values that minimize some measure of the error between these measurements and the corresponding model prediction.

The goal of our research is to develop effective, fast, and scalable methods, techniques and tools for automated parameter estimation for computational analysis of biological systems. Our approach considers a generalized form of the problem provided that traditional fitting to experimental measurements is enhanced by considering several explicit hypotheses about expected behavior of the system. We employ computer science approaches, methods and techniques as known from the analysis of computer systems (like model checking) to fit parameters according to the expected behavior.
Requirements

Candidates must hold a PhD degree (or equivalent) awarded after 1 April 2008, should be highly motivated and have either a strong background in systems biology, molecular biology, cell biology or biochemistry OR a strong background in informatics or computational modeling and an interest in biological systems. Candidate must have excellent analytical skills, and strong interpersonal and communication skills.

The deadline for applications is March 31, 2012. The gross salary is about 2200 EUR per month. The post is available from 1 September 2012, but the precise starting date is negotiable.

Interested candidates should email their CV, list of publications, brief statement of interest and career goals, names and contact information for 3 references contained in one single PDF file to:

Prof. Lubos Brim
Masaryk University Brno
Faculty of Informatics
Botanicka 68a, 602 00 Brno
Czech Republic
Email: brim at fi dot muni dot cz

Integrative Network Biology 2012: Network Medicine

Thu, 05 Jan 2012 15:26:04 +0900

The conference will take place near Hamlet's City, Helsingør (Denamark)
http://www.networkbio.org

Early Registration Deadline: 18th March 2012
Poster Abstract Submission Deadline: 18th March 2012

11th Annual Symposium:Systems Biology & the Microbiome

Thu, 05 Jan 2012 15:23:02 +0900

Seattle, Washington, USA

http://systemsbiology.org/symposium/

HD Physiology International Symposium

Tue, 13 Dec 2011 15:22:19 +0900

Takeda Hall, University of Tokyo
http://hd-physiology.jp/sympo2012/

Okinawa Institute of Science and Technology (OIST) is now opening a Graduate School.

Sat, 10 Dec 2011 12:02:28 +0900

Hiroaki Kitano and Igor Goryanin are serving there as professors (adjunct).
For interested students, please visit http://www.oist.jp/graduate-school
Broshure can be downloaded from http://mediasv.oist.jp/images/stories/page/graduate-school/oist_brochure_20111013_final.pdf

Okinawa Institute of Science and Technology (OIST) is now opening a Graduate School.

Sat, 10 Dec 2011 11:59:38 +0900

Doctoral Candidate (PhD student) in Systems Biochemistry

Thu, 24 Nov 2011 10:59:07 +0900

(m/f)Application End : Friday November 25 2011
The University of Luxembourg is looking for the newly established Luxembourg Centre for Systems Biomedicine (LCSB) for a Doctoral Candidate (PhD student) in Systems Biochemistry (m/f)

Ref. I1C-DIR-COM-11ICOO
Fixed-term contract 3 years, 40h/week renewable once Student and Employee status
The PhD student will be a member of the highly interdisciplinary research centre, integrating experimental biological and computational biology approaches in order to develop the foundation of a future predicitive, preventive and personalised medicine.

Area:
Biochemistry/Medical Biochemistry/Neurochemistry.

Mission:
Experimental determination of metabolic flux and concentration is a critical tool for developing understanding of the physiological state of a cell. Using isotopically labeled substrates with different
labeling patterns, experimental techniques are used to measure the mass isotopomer distributions of select metabolites. Estimation of metabolic flux is by integration of mass isotopomer distributions with
an isotopomer (isotope isomer) mapping model, that traces the path of each isotopomer through a metabolic network. Recently an algorithm for automated generation of draft genome-scale isotopomer mapping models has been develope. The latest reconstruction of human metabolism (Recon 2.0) is a stoichiometric model of a generic human cell. It is necessary to tailor Recon 2.0 to represent the metabolic capabilities of a particular cell type of interest. Extensive manual curation of neurochemical experimental data is necessary to tailor Recon 2.0 to accurately represent the metabolism of a normal neuron. A tailored stoichiometric model of a dopaminergic neuron, that also represents atom transitions for each reaction, would be an invaluable resource for estimation of metabolic flux and concentration in cultured dopaminergic cell lines.

Tasks:
To address the aforementioned challenges, the PhD project objectives are:
Reconstruction of a tailored stoichiometric model of a normal dopaminergic neuron by literature review.

Manual curation of an existing algorithmically created draft isotopomer mapping model of Recon 2.0 to retain only biochemically realistic atom transitions.Biological interpretation of whole cell metabolic flux and concentration data in normal and diseased dopaminergic neuronal cells toward a deeper understanding of Parkinsonism pathogenesis.

Profile:
A broad and deep knowledge of metabolic biochemistry e.g. M.Sc. level Medical Biochemist, Biochemist, Neurochemist.Excellent English writing and speaking skills.

Offer:
Contribution to an international, interdisciplinary project: Dr. Karsten Hiller, LCSB, Dr. Ronan Fleming, Center for Systems Biology, University of Iceland (CSBUI).
International interdisciplinary training: In the first year, a 6 month training period in metabolic networkreconstruction & modeling at the CSBUI.
The University of Luxembourg offers competitive salaries and is an equal opportunity employer.

Application:
All applications (in English) should contain the following documents:
A detailed curriculum vitae
Cover letter mentioning the reference number
List of publications
Description of past research experience and future interests
Name and addresses of three referees
Please send your electronic applications until the 23rd Dec 2011 to the following address: katrin.effenberger at uni.lu

The Dynamics of Disease - Workshop in Medical Systems Biology

Wed, 09 Nov 2011 10:34:47 +0900

Barnes Wallis Building, Manchester, UK
http://dtc.mib.manchester.ac.uk/2011/07/the-dynamics-of-disease-28-nov-2-dec-2011/